Featured Research

from universities, journals, and other organizations

Oncolytic viruses effectively target and kill pancreatic cancer stem cells, research finds

Date:
May 9, 2011
Source:
Digestive Disease Week
Summary:
Oncolytic viruses quickly infect and kill cancer stem cells, which may provide a treatment for tumors that are resistant to conventional chemotherapy and radiation, particularly pancreatic cancer, according to new research. The findings are especially important since pancreatic cancer has a poor prognosis and is difficult to detect and treat at early stages.

Oncolytic viruses quickly infect and kill cancer stem cells, which may provide a treatment for tumors that are resistant to conventional chemotherapy and radiation, particularly pancreatic cancer, according to new research from Memorial Sloan-Kettering Cancer Center in New York. The findings are especially important since pancreatic cancer has a poor prognosis and is difficult to detect and treat at early stages.

Investigators led by Joyce Wong, MD, surgical researcher with Memorial Sloan-Kettering Cancer Center, investigated whether they could use oncolytic viruses, which are naturally occurring viruses that have been genetically engineered to be safe and express tracking genes, as a possible therapy against pancreatic cancer stem cells. These stem cells are thought to cause disease recurrence and metastasis, even after therapy, and oncolytic viruses may offer a new treatment strategy.

"What we learned is that oncolytic viruses have been engineered to selectively target cancer cells and have a low toxicity profile in animal studies," said Dr. Wong. "Targeting the cancer stem cell may enhance our ability to eradicate tumors and prevent future recurrence of disease."

While much research has been performed on isolating the cancer stem cell from various hematologic cancers, this research was based on the presence or absence of certain cell surface markers. Numerous mechanisms of how these cancer stem cells resist chemotherapy and radiation have also been examined. But to date, there have not been any studies evaluating whether genetically engineered viruses can target and kill pancreatic cancer stem cells.

Investigators sought to determine whether the viruses containing a marker gene that expresses green fluorescent protein could infect pancreatic cancer stem cells and ultimately kill the cancer stem cell. Their findings were promising and documented that viral activity was correlated with green fluorescent protein expression.

Dr. Wong added that future studies are warranted to determine whether oncolytic virus administration in vivo will help eradicate tumors and prevent future disease recurrence, and that while these initial findings are encouraging, further study is necessary to see whether oncolytic viruses will be clinically useful as a therapy.

Dr. Wong is presenting these data May 9 at Digestive Disease Week® 2011 in Chicago.


Story Source:

The above story is based on materials provided by Digestive Disease Week. Note: Materials may be edited for content and length.


Cite This Page:

Digestive Disease Week. "Oncolytic viruses effectively target and kill pancreatic cancer stem cells, research finds." ScienceDaily. ScienceDaily, 9 May 2011. <www.sciencedaily.com/releases/2011/05/110509113725.htm>.
Digestive Disease Week. (2011, May 9). Oncolytic viruses effectively target and kill pancreatic cancer stem cells, research finds. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2011/05/110509113725.htm
Digestive Disease Week. "Oncolytic viruses effectively target and kill pancreatic cancer stem cells, research finds." ScienceDaily. www.sciencedaily.com/releases/2011/05/110509113725.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) — Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) — New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins