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Sensitizing prostate cancer to radiotherapy

Date:
May 9, 2011
Source:
Journal of Clinical Investigation
Summary:
Men with prostate cancer whose disease has spread locally are primarily treated with radiation therapy. However, disease recurs in approximately half of these individuals. Strategies to enhance the efficacy of this treatment are clearly needed. Researchers have now developed an approach that enhances the therapeutic effects of radiation therapy in mice bearing human prostate cancer xenografts, which they hope can be developed for clinical use.

Men with prostate cancer whose disease has spread locally from inside the prostate to immediately outside it are primarily treated with radiation therapy.

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However, disease recurs in approximately half of these individuals. Strategies to enhance the efficacy of this treatment and thereby decrease the incidence of disease recurrence are clearly needed. Shawn Lupold and colleagues, at Johns Hopkins University School of Medicine, Baltimore, have now developed an approach that enhances the therapeutic effects of radiation therapy in mice bearing human prostate cancer xenografts.

Specifically, they selectively sensitized the prostate cancer cells to radiation therapy by knocking down expression of the gene responsible for making the protein DNAPK, which is important for repairing damaged DNA. Lupold and colleagues hope that this approach can be developed for the treatment of locally advanced prostate cancer.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xiaohua Ni, Yonggang Zhang, Judit Ribas, Wasim H. Chowdhury, Mark Castanares, Zhewei Zhang, Marikki Laiho, Theodore L. DeWeese, Shawn E. Lupold. Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI45109

Cite This Page:

Journal of Clinical Investigation. "Sensitizing prostate cancer to radiotherapy." ScienceDaily. ScienceDaily, 9 May 2011. <www.sciencedaily.com/releases/2011/05/110509122723.htm>.
Journal of Clinical Investigation. (2011, May 9). Sensitizing prostate cancer to radiotherapy. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2011/05/110509122723.htm
Journal of Clinical Investigation. "Sensitizing prostate cancer to radiotherapy." ScienceDaily. www.sciencedaily.com/releases/2011/05/110509122723.htm (accessed December 17, 2014).

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