Featured Research

from universities, journals, and other organizations

Monkey studies reveal promising vaccine approach for HIV

Date:
May 12, 2011
Source:
Oregon Health & Science University
Summary:
Researchers have developed a vaccine candidate in rhesus macaque monkeys that may eventually lead to a vaccine against Human Immunodeficiency Virus (HIV).

Research conducted at Oregon Health & Science University's Vaccine and Gene Therapy Institute (VGTI) has developed a vaccine candidate in non-human primates that may eventually lead to a vaccine against Human Immunodeficiency Virus (HIV).

Related Articles


Details of this advance are published in the advance online edition of the journal Nature. The paper will also be published in an upcoming print addition of the journal.

The research team, led by Louis Picker, M.D., associate director of the OHSU VGTI and director of the VGTI's vaccine program, produced a vaccine candidate that programs the immune system of non-human primates to respond more swiftly to the presence of a primate version of HIV than it normally would. The team also included researchers from the National Cancer Institute-Frederick and the International AIDS Vaccine Initiative.

The VGTI researchers tested their vaccine candidate in rhesus macaque monkeys at the Oregon National Primate Research Center using a monkey form of HIV called Simian Immunodeficiency Virus (SIV). Of the monkeys that received the vaccine candidate, just more than half controlled replication of the virus to the extent that even the most sensitive tests could not detect signs of SIV.

To date, the vast majority of these animals have maintained control over the virus for more than a year, gradually losing any signs that they had ever been infected. In contrast, the macaques in the unvaccinated control group developed the monkey form of AIDS.

The researchers say that their work suggests that the immune responses elicited by this new vaccine candidate might completely clear SIV from animals that were initially infected. In comparison, antiretroviral therapy is able to control the disease, but cannot clear the virus from its hiding place within the immune systems own cells.

The VGTI team has been working for over ten years on its vaccine candidate, which is unique in using Cytomegalovirus (CMV) as the transport system used to introduce the vaccine into the body. CMV was chosen because it is believed that most people are already infected with CMV, but for the majority, the virus causes little or no symptoms. In addition, once a person is infected with CMV, this virus remains in the body for life. Picker and his team hypothesized that if such a persistent virus were used as a vector it could create and maintain resistance against HIV by programming a portion of the body's immune system called effector memory T-cells to be constantly on the alert for the virus.

"The next step in vaccine development is to test the vaccine candidate in clinical trials in humans. For a human vaccine the CMV vector would be weakened sufficiently so that it does not cause illness, but will still protect against HIV, " said Dr. Picker.

The National Institutes of Health and, the International AIDS Vaccine Initiative provided funding for this research.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Scott G. Hansen, Julia C. Ford, Matthew S. Lewis, Abigail B. Ventura, Colette M. Hughes, Lia Coyne-Johnson, Nathan Whizin, Kelli Oswald, Rebecca Shoemaker, Tonya Swanson, Alfred W. Legasse, Maria J. Chiuchiolo, Christopher L. Parks, Michael K. Axthelm, Jay A. Nelson, Michael A. Jarvis, Michael Piatak, Jeffrey D. Lifson, Louis J. Picker. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature, 2011; DOI: 10.1038/nature10003

Cite This Page:

Oregon Health & Science University. "Monkey studies reveal promising vaccine approach for HIV." ScienceDaily. ScienceDaily, 12 May 2011. <www.sciencedaily.com/releases/2011/05/110511134217.htm>.
Oregon Health & Science University. (2011, May 12). Monkey studies reveal promising vaccine approach for HIV. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2011/05/110511134217.htm
Oregon Health & Science University. "Monkey studies reveal promising vaccine approach for HIV." ScienceDaily. www.sciencedaily.com/releases/2011/05/110511134217.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins