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Unraveling the complex genetics of autism

Date:
June 8, 2011
Source:
Cell Press
Summary:
Autism spectrum disorders (ASDs) are devastating developmental disorders characterized by altered social interactions and behavior. Although genetic risks are known to contribute to the development of ASDs, the genetic causes of the disease are not well understood. Now, three new papers provide new insight into the diversity of the genetic abnormalities that contribute to autism and represent a step towards the future design of treatments specifically targeted to different kinds of autism.

Autism spectrum disorders (ASDs) are devastating developmental disorders characterized by altered social interactions and behavior. Although genetic risks are known to contribute to the development of ASDs, the genetic causes of the disease are not well understood. Now, three papers published by Cell Press in the June 9 issue of the journal Neuron provide new insight into the diversity of the genetic abnormalities that contribute to autism and represent a step towards the future design of treatments specifically targeted to different kinds of autism.

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To unravel the genetic mutations linked with ASDs, two separate research groups searched for "copy number variants" (CNVs), duplications or deletions of one or more sections of DNA, in genetic samples from over 1000 ASD families that were recruited as part of the Simons Simplex Collection project. The authors compared DNA from affected and unaffected siblings using distinct versions of a sensitive and powerful genetic screening technique which, combined with the large sample size, allowed discovery of CNVs on a finer scale than was previously possible.

"We observed a higher incidence of de novo (new) CNVs in children with ASD than their unaffected siblings," explains Dr. Michael Wigler from Cold Spring Harbor Laboratory who led one of the studies. "The functions of the genes in the regions of de novo variation point to a great diversity of genetic causes, but also suggest functional convergence. In addition, our results show that, relative to males, females have a greater resistance to autism from genetic causes, which raises the question of the fate of female carriers." In a companion study led by Dr. Dennis Vitkup from Columbia University, the CNVs identified in Dr. Wigler's study were analyzed using a new method which revealed that the affected genes are part of a large network involved in the development of synapses, key sites of communication between neurons.

A separate collaborative and multi-site study led by Dr. Matthew W. State from Yale University identified six rare recurrent de novo CNVs and, along with Dr. Wigler's group, found a significant association of ASD with de novo duplications of a chromosomal region that, when deleted, causes Williams-Beuren syndrome, a rare neurodevelopmental disorder which is associated with a highly social personality. "Finding strong evidence that at one position in the genome increases in the genetic material lead to ASD, while losses at precisely the same region lead to a highly social personality, was particularly exciting. This relatively small genomic interval clearly holds important clues to understanding the social brain," explains Dr. State.

Taken together, results from these studies highlight the importance of diverse rare genetic variations in autism. "The diversity implies that a treatment for one form of autism may have no value for the majority," says Dr. Wigler. "Once the specific genes mutated in ASDs are known with confidence, we can begin to think with clarity about problems specific to individuals within categories of causation rather than attempting to manage a conglomerate disorder." Dr. State adds, "These studies represent a significant step forward in understanding the genomic architecture of ASDs and provide important new points of traction in elaborating the molecular mechanisms and developmental neurobiology underlying ASDs. This type of knowledge is a critical first step in developing novel treatment approaches."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal References:

  1. Christian P. Schaaf, Huda Y. Zoghbi. Solving the Autism Puzzle a Few Pieces at a Time. Neuron, 2011, Volume 70, Issue 5, 806-808 DOI: 10.1016/j.neuron.2011.05.025
  2. Stephan J. Sanders, A. Gulhan Ercan-Sencicek, Vanessa Hus, Rui Luo, Michael T. Murtha, Daniel Moreno-De-Luca, Su H. Chu, Michael P. Moreau, Abha R. Gupta, Susanne A. Thomson, Christopher E. Mason, Kaya Bilguvar, Patricia B.S. Celestino-Soper, Murim Choi, Emily L. Crawford, Lea Davis, Nicole R. Davis Wright, Rahul M. Dhodapkar, Michael DiCola, Nicholas M. DiLullo, Thomas V. Fernandez, Vikram Fielding-Singh, Daniel O. Fishman, Stephanie Frahm, Rouben Garagaloyan, Gerald S. Goh, Sindhuja Kammela, Lambertus Klei, Jennifer K. Lowe, Sabata C. Lund, Anna D. McGrew, Kyle A. Meyer, William J. Moffat, John D. Murdoch, Brian J. O'Roak, Gordon T. Ober, Rebecca S. Pottenger, Melanie J. Raubeson, Youeun Song, Qi Wang, Brian L. Yaspan, Timothy W. Yu, Ilana R. Yurkiewicz, Arthur L. Beaudet, Rita M. Cantor, Martin Curland, Dorothy E. Grice, Murat Gόnel, Richard P. Lifton, Shrikant M. Mane, Donna M. Martin, Chad A. Shaw, Michael Sheldon, Jay A. Tischfield, Christopher A. Walsh, Eric M. Morrow, David H. Ledbetter, Eric Fombonne, Catherine Lord, Christa Lese Martin, Andrew I. Brooks, James S. Sutcliffe, Edwin H. Cook, Daniel Geschwind, Kathryn Roeder, Bernie Devlin, Matthew W. State. Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism. Neuron, 2011; 70 (5): 863-885 DOI: 10.1016/j.neuron.2011.05.002
  3. Dan Levy, Michael Ronemus, Boris Yamrom, Yoon-ha Lee, Anthony Leotta, Jude Kendall, Steven Marks, B. Lakshmi, Deepa Pai, Kenny Ye, Andreas Buja, Abba Krieger, Seungtai Yoon, Jennifer Troge, Linda Rodgers, Ivan Iossifov, Michael Wigler. Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders. Neuron, 2011; 70 (5): 886-897 DOI: 10.1016/j.neuron.2011.05.015
  4. Sarah R. Gilman, Ivan Iossifov, Dan Levy, Michael Ronemus, Michael Wigler, Dennis Vitkup. Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses. Neuron, 2011; 70 (5): 898-907 DOI: 10.1016/j.neuron.2011.05.021

Cite This Page:

Cell Press. "Unraveling the complex genetics of autism." ScienceDaily. ScienceDaily, 8 June 2011. <www.sciencedaily.com/releases/2011/06/110608122538.htm>.
Cell Press. (2011, June 8). Unraveling the complex genetics of autism. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2011/06/110608122538.htm
Cell Press. "Unraveling the complex genetics of autism." ScienceDaily. www.sciencedaily.com/releases/2011/06/110608122538.htm (accessed March 5, 2015).

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