Featured Research

from universities, journals, and other organizations

New animal study shows promise for development of Parkinson's disease drug

Date:
June 11, 2011
Source:
IOS Press
Summary:
Few treatments for Parkinson's disease (PD) restore function for extended periods. In a new study, an international group of researchers reports that platelet-derived growth factor-BB restored function in rodents and shows promise as a clinical candidate drug for treatment of PD.

Few treatments for Parkinson's disease (PD) restore function for extended periods. In a new study published in the inaugural issue issue of the Journal of Parkinson's Disease, an international group of researchers reports that platelet-derived growth factor-BB (PDGF-BB) restored function in rodents and shows promise as a clinical candidate drug for treatment of PD.

Related Articles


Parkinson's disease is the second most common neurodegenerative disorder, affecting 1-2% of the population over the age of 65. It is characterized by loss of brain cells (neurons) from the mid-brain which use the neurotransmitter dopamine to help control voluntary movements. Investigators from NeuroNova AB, Stockholm, Sweden, the Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, The Parkinson's Institute, Sunnyvale, CA, USA, and Motac Neuroscience Ltd, Manchester, UK, found that behavioral, tissue and biochemical changes in experimental models of Parkinson's disease in rodents could be counteracted by infusion of PDGF-BB. This could offer an alternative strategy to restore function in PD.

"In animal models of nigrostriatal injury, a two weeks treatment with platelet-derived growth factor-BB resulted in long-lasting restoration of striatal dopamine transporter binding sites and expression of nigral tyrosine hydroxylase," commented Anders Haegerstrand, MD, PhD, Chief Scientific Officer, NeuroNova AB, Stockholm, Sweden."It also normalized amphetamine-induced rotational behavior in 6-hydroxydopamine lesioned rats. Platelet-derived growth factor-BB promoted proliferation of neural progenitor cells in the subventricular zone. The effects on dopaminergic neurons and functional recovery could be blocked by co-infusion with a proliferation inhibitor, indicating a link between the proliferative and anti-parkinsonian effects. Based on the current data, we consider platelet-derived growth factor-BB a clinical candidate drug for treatment of Parkinson's disease."

The study demonstrated for the first time a functional relevance of a PDGF-induced cell proliferation in a model of CNS disease. In the rats studied, normalization of behavior after PDGF-BB treatment lasted for 10 weeks. PDGF-BB is already in clinical trial at NeuroNova.


Story Source:

The above story is based on materials provided by IOS Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Olof Zachrisson, Ming Zhao, Annica Andersson, Karin Dannaeus, Johan Hδggblad, Ruben Isacson, Elisabet Nielsen, Cesare Patrone, Harriet Rφnnholm, Lilian Wikstrom, Kristofer Delfani, Alison L. McCormack, Theo Palmer, Donato A. Di Monte, Michael P. Hill, Ann Marie Janson Lang, and Anders Haegerstrand. Restorative Effects of Platelet Derived Growth Factor-BB in Rodent Models of Parkinson's Disease. Journal of Parkinson's Disease, 2011; 1 (1) DOI: 10.3233/JPD-2011-0003

Cite This Page:

IOS Press. "New animal study shows promise for development of Parkinson's disease drug." ScienceDaily. ScienceDaily, 11 June 2011. <www.sciencedaily.com/releases/2011/06/110609123336.htm>.
IOS Press. (2011, June 11). New animal study shows promise for development of Parkinson's disease drug. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2011/06/110609123336.htm
IOS Press. "New animal study shows promise for development of Parkinson's disease drug." ScienceDaily. www.sciencedaily.com/releases/2011/06/110609123336.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) — Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) — Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins