Featured Research

from universities, journals, and other organizations

Cholesterol boosts antibiotic resistance in H. pylori

Date:
June 20, 2011
Source:
American Society for Microbiology
Summary:
New research suggests that cholesterol boosts resistance in Helicobacter pylori both to many antibiotics and to the endogenous antimicrobial peptide, LL-37. A complete understanding of the pathway of cholesterol uptake might lead to novel strategies thwarting H. pylori by blocking that pathway.

New research suggests that cholesterol boosts resistance in Helicobacter pylori both to many antibiotics and to the endogenous antimicrobial peptide, LL-37. A complete understanding of the pathway of cholesterol uptake might lead to novel strategies thwarting H. pylori by blocking that pathway, says corresponding author David McGee of Louisiana State University. The research is published in the June 2011 issue of the journal Antimicrobial Agents and Chemotherapy.

H. pylori infects one third of Americans, causing gastritis and peptic ulcers, and costing $10 billion annually. Antibiotic therapy is recommended, but resistance, often leading to treatment failures, is becoming increasingly common, even following the now-standard triple drug therapy.

In the study, the investigators grew H. pylori in the presence or absence of cholesterol, and treated the bacteria with different classes and concentrations of antibiotics, comparing the populations of surviving bacteria. "We found that H. pylori grown with cholesterol displayed a very dramatic increase in resistance to many antibiotics, bismuth, and to LL-37," says McGee.

"It would be important to learn whether we can manipulate the ability to clear H. pylori infections in animals and humans by lowering cholesterol either through dietary means or cholesterol-lowering drugs (statins)," says McGee. "There are already data showing that H. pylori-infected patients have elevated serum cholesterol levels, suggesting the bacteria manipulate the human host to produce more cholesterol." Additionally, he says, a study of 500 patients found that taking statins lowered the severity of chronic gastritis, which is also caused by H. pylori. But some statins work, and others don't, he says. And so far, no studies have combined antibiotics with statins. Thus, it is too soon to make recommendations to patients on their use to lower cholesterol, he says.

Interestingly, McGee says his research would not have been possible without the help of a high school student. Alika George, now an undergraduate at the University of Louisiana, collected some of the data, and urged McGee to include pepto bismol (bismuth) in the study, while taking part in a summer enrichment program for minority high school students, which was supported by Louisiana State University's Office of Multicultural Affairs. "I feel it is vital to be supportive of programs like this to give students opportunities they otherwise would not have had," says McGee.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. J. McGee, A. E. George, E. A. Trainor, K. E. Horton, E. Hildebrandt, T. L. Testerman. Cholesterol Enhances Helicobacter pylori Resistance to Antibiotics and LL-37. Antimicrobial Agents and Chemotherapy, 2011; 55 (6): 2897 DOI: 10.1128/AAC.00016-11

Cite This Page:

American Society for Microbiology. "Cholesterol boosts antibiotic resistance in H. pylori." ScienceDaily. ScienceDaily, 20 June 2011. <www.sciencedaily.com/releases/2011/06/110617184937.htm>.
American Society for Microbiology. (2011, June 20). Cholesterol boosts antibiotic resistance in H. pylori. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/06/110617184937.htm
American Society for Microbiology. "Cholesterol boosts antibiotic resistance in H. pylori." ScienceDaily. www.sciencedaily.com/releases/2011/06/110617184937.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins