Featured Research

from universities, journals, and other organizations

Unexpected discovery on hormone secretion

Date:
July 28, 2011
Source:
Institut de recherches cliniques de Montreal
Summary:
Geneticists have made an unexpected discovery on hormone secretion. Contrary to common belief, the researchers found that pituitary cells are organized in structured networks.

A team of geneticists at the Institut de recherches cliniques de Montrιal (IRCM), directed by Dr. Jacques Drouin, made an unexpected discovery on hormone secretion. Contrary to common belief, the researchers found that pituitary cells are organized in structured networks.

The scientific breakthrough was published July 26 by the scientific journal Proceedings of the National Academy of Sciences (PNAS).

The pituitary gland, located at the base of the brain, secretes the hormones that preserve the balance between all other glands of the endocrine system, which includes all hormone-producing organs.

"Each hormone in the pituitary gland is secreted by a specific type of cells," explains Dr. Drouin, Director of the Molecular Genetics research unit at the IRCM. "Until now, we believed that these cells were randomly distributed throughout the pituitary gland."

By using three-dimensional imaging, the researchers discovered that the pituitary gland's secreting cells are rather organized into highly-structured networks. Inside these networks, each cell remains in contact with other cells of the same type, so as to form continuous sheets of cells. In fact, cells of the same lineage can recognize, exchange signals and even act in concert with one another.

"We were the first to reveal this three-dimensional organization," says Lionel Budry, graduate student in Dr. Drouin's laboratory and first co-author of the study. "In addition to discovering the cell's structure, we showed its importance for the development and function of the pituitary gland."

"We studied two networks of cells: cells that modulate our responses to stress, and cells that control reproduction," adds Dr. Drouin. "Disturbing these networks could be associated with hormone deficiencies."

This research project was conducted in collaboration with the team of experts in three-dimensional imaging at the Universitι de Montpellier directed by Dr. Patrice Mollard, which includes Chrystel Lafont, who is first co-author of the article with Lionel Budry.

Research carried out at the IRCM was funded by the Canadian Institutes of Health Research (CIHR) and the Canadian Cancer Society.


Story Source:

The above story is based on materials provided by Institut de recherches cliniques de Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Budry, C. Lafont, T. El Yandouzi, N. Chauvet, G. Conejero, J. Drouin, P. Mollard. Related pituitary cell lineages develop into interdigitated 3D cell networks. Proceedings of the National Academy of Sciences, 2011; 108 (30): 12515 DOI: 10.1073/pnas.1105929108

Cite This Page:

Institut de recherches cliniques de Montreal. "Unexpected discovery on hormone secretion." ScienceDaily. ScienceDaily, 28 July 2011. <www.sciencedaily.com/releases/2011/07/110727121712.htm>.
Institut de recherches cliniques de Montreal. (2011, July 28). Unexpected discovery on hormone secretion. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2011/07/110727121712.htm
Institut de recherches cliniques de Montreal. "Unexpected discovery on hormone secretion." ScienceDaily. www.sciencedaily.com/releases/2011/07/110727121712.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins