Featured Research

from universities, journals, and other organizations

Nicotine can protect the brain from Parkinson's disease, research suggests

Date:
August 1, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
If you've ever wondered if nicotine offered society any benefit, a new study offers a surprising answer. Nicotine can protect the brain against Parkinson's disease, the research suggests, and the discovery of how nicotine does this may lead to entirely new types of treatments for the disease.

If you've ever wondered if nicotine offered society any benefit, a new study published in The FASEB Journal offers a surprising answer. Nicotine can protect the brain against Parkinson's disease, the research suggests, and the discovery of how nicotine does this may lead to entirely new types of treatments for the disease.

Related Articles


"This study raises the hope for a possible neuroprotective treatment of patients at an early step of the disease or even before at a stage where the disease has not been diagnosed according to motor criteria," said Patrick P. Michel, co-author of the study from the Institut du Cerveau et de la Moelle Épinière, Hôpital de la Salpêtrière, in Paris, France.

To make this discovery, scientists used mice genetically engineered without a specific nicotine receptor (the alpha-7 subtype) and mice with a functional receptor. Using tissue from mouse embryos, researchers prepared brain cultures using conditions that favor the slowly progressing loss of dopamine neurons, a hallmark of the disease. The scientists found that nicotine had the potential to rescue dopamine neurons in cultures from normal mice, but not in cultures from mice without the nicotine receptor. These findings suggest that it may be feasible to develop novel therapies for Parkinson's disease that target nicotine receptors, particularly the alpha-7 nicotine receptor.

"If you're a smoker, don't get too excited," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Even if smoking protects you from Parkinson's, you might not live long enough to develop the disease because smoking greatly increases the risk for deadly cancers and cardiovascular diseases. But now, we should be able find non-toxic ways to hit the same target."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Toulorge, S. Guerreiro, A. Hild, U. Maskos, E. C. Hirsch, P. P. Michel. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2. The FASEB Journal, 2011; 25 (8): 2563 DOI: 10.1096/fj.11-182824

Cite This Page:

Federation of American Societies for Experimental Biology. "Nicotine can protect the brain from Parkinson's disease, research suggests." ScienceDaily. ScienceDaily, 1 August 2011. <www.sciencedaily.com/releases/2011/08/110801111738.htm>.
Federation of American Societies for Experimental Biology. (2011, August 1). Nicotine can protect the brain from Parkinson's disease, research suggests. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2011/08/110801111738.htm
Federation of American Societies for Experimental Biology. "Nicotine can protect the brain from Parkinson's disease, research suggests." ScienceDaily. www.sciencedaily.com/releases/2011/08/110801111738.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins