A working group of the International Osteoporosis Foundation (IOF) has issued a literature review of prospective controlled studies comparing the efficacy and safety of two minimally invasive techniques for vertebral augmentation after spine fracture: vertebroplasty (VP) and balloon kyphoplasty (BKP). The review also lists important recommendations to facilitate the comparison of future studies and highlights research questions still unresolved.
Vertebral fractures, most often due to osteoporosis, are associated with acute or chronic back pain, disability and kyphosis (stooped back). One in five women with a vertebral fracture will sustain another within a year, which may lead to a 'cascade' of fractures. Vertebral fractures impact severely on quality of life and may have serious health consequences such as spinal deformity, immobility, decreased pulmonary function, early satiety and impaired gait. Clinical vertebral fractures are also associated with an 8-fold increase in mortality.
Conservative treatment of vertebral fractures is typically through rest, pain medication, bracing and muscle relaxants. VP and BKP are two minimally invasive techniques that consist of inserting a bone cement into the compressed vertebra and stabilising the fracture.
In the studies observed, the review found that:
Kristina Åkesson, chair of the IOF Fracture Working Group and Professor at the Department of Orthopedics, Skåne University Hospital Malmö in Sweden, stated, "Referring physicians should be aware that VP and BKP are available options for the management of vertebral compression fractures, with possible clinical benefits to their patients in terms of acute pain relief and improved quality of life. However, longer follow-up of patients are needed to ensure the efficacy and safety of these techniques, which should not be considered as a substitute for the medical management of osteoporosis, vitally needed in these patients at high risk of other fractures."
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