Featured Research

from universities, journals, and other organizations

Surprising condition occurs in lungs after an invasion of mold, study shows

Date:
August 4, 2011
Source:
Montana State University
Summary:
Researchers have found a surprising condition that occurs in the lungs after an invasion of a common, but potentially dangerous, mold.

Researchers led by Montana State University have found a surprising condition that occurs in the lungs after an invasion of a common mold that can cause deadly infections in humans.

Related Articles


In the most oxygen-rich environment in the body -- the lungs -- the scientists discovered a shortage of oxygen. The shortage resulted from inflammation and invasive growth of the mold, which greatly reduced the oxygen available to the pathogenic mold Aspergillus fumigatus.

The mold is generally found in hay, soils and compost piles and can cause a variety of lung infections when inhaled by humans. The most lethal of those infections is invasive aspergillosis, which can kill 30 to 90 percent of its victims depending on the patient population. Most susceptible are people who have had organ transplants, HIV, chemotherapy or other medical treatments that weaken their ability to fight off infection.

"We think this (the lack of oxygen) is a really big stress on the pathogen," said Nora Grahl, a doctoral candidate at MSU.

Grahl led the study that's adding knowledge to the field of infectious disease and was published in the July 21 issue of "PLoS Pathogens." Based in Dr. Robert Cramer's laboratory in MSU's Department of Immunology and Infectious Diseases, the study was the first to show a strong link between hypoxia, or low oxygen levels in the lungs, and fungal infections, Grahl said. She added that the research was unique because little research has been done on the microenvironments encountered by Aspergillus fumigatus in such detail during infection.

The study was conducted in mice and showed a variety of ways that the lungs and mold respond to each other. The scientists noted, for example, that low levels of oxygen are just one of many challenges that mold has to overcome before it can cause a lung infection. When the shortage occurs, though, microbes may adapt through fermentation or other changes in metabolism. An important finding of the study was that the mold's fermentation could also influence the host immune response to the pathogen.

Cramer said most microbes can use fermentation to generate energy during hypoxia, but Grahl has also found mutant strains of the mold that use respiration instead. As a result, the researchers are interested in continuing to study respiration as it relates to Aspergillus fumigatus pathogenesis.


Story Source:

The above story is based on materials provided by Montana State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nora Grahl, Srisombat Puttikamonkul, Jeffrey M. Macdonald, Michael P. Gamcsik, Lisa Y. Ngo, Tobias M. Hohl, Robert A. Cramer. In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis. PLoS Pathogens, 2011; 7 (7): e1002145 DOI: 10.1371/journal.ppat.1002145

Cite This Page:

Montana State University. "Surprising condition occurs in lungs after an invasion of mold, study shows." ScienceDaily. ScienceDaily, 4 August 2011. <www.sciencedaily.com/releases/2011/08/110804124702.htm>.
Montana State University. (2011, August 4). Surprising condition occurs in lungs after an invasion of mold, study shows. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2011/08/110804124702.htm
Montana State University. "Surprising condition occurs in lungs after an invasion of mold, study shows." ScienceDaily. www.sciencedaily.com/releases/2011/08/110804124702.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins