Featured Research

from universities, journals, and other organizations

Surprising condition occurs in lungs after an invasion of mold, study shows

Date:
August 4, 2011
Source:
Montana State University
Summary:
Researchers have found a surprising condition that occurs in the lungs after an invasion of a common, but potentially dangerous, mold.

Researchers led by Montana State University have found a surprising condition that occurs in the lungs after an invasion of a common mold that can cause deadly infections in humans.

In the most oxygen-rich environment in the body -- the lungs -- the scientists discovered a shortage of oxygen. The shortage resulted from inflammation and invasive growth of the mold, which greatly reduced the oxygen available to the pathogenic mold Aspergillus fumigatus.

The mold is generally found in hay, soils and compost piles and can cause a variety of lung infections when inhaled by humans. The most lethal of those infections is invasive aspergillosis, which can kill 30 to 90 percent of its victims depending on the patient population. Most susceptible are people who have had organ transplants, HIV, chemotherapy or other medical treatments that weaken their ability to fight off infection.

"We think this (the lack of oxygen) is a really big stress on the pathogen," said Nora Grahl, a doctoral candidate at MSU.

Grahl led the study that's adding knowledge to the field of infectious disease and was published in the July 21 issue of "PLoS Pathogens." Based in Dr. Robert Cramer's laboratory in MSU's Department of Immunology and Infectious Diseases, the study was the first to show a strong link between hypoxia, or low oxygen levels in the lungs, and fungal infections, Grahl said. She added that the research was unique because little research has been done on the microenvironments encountered by Aspergillus fumigatus in such detail during infection.

The study was conducted in mice and showed a variety of ways that the lungs and mold respond to each other. The scientists noted, for example, that low levels of oxygen are just one of many challenges that mold has to overcome before it can cause a lung infection. When the shortage occurs, though, microbes may adapt through fermentation or other changes in metabolism. An important finding of the study was that the mold's fermentation could also influence the host immune response to the pathogen.

Cramer said most microbes can use fermentation to generate energy during hypoxia, but Grahl has also found mutant strains of the mold that use respiration instead. As a result, the researchers are interested in continuing to study respiration as it relates to Aspergillus fumigatus pathogenesis.


Story Source:

The above story is based on materials provided by Montana State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nora Grahl, Srisombat Puttikamonkul, Jeffrey M. Macdonald, Michael P. Gamcsik, Lisa Y. Ngo, Tobias M. Hohl, Robert A. Cramer. In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis. PLoS Pathogens, 2011; 7 (7): e1002145 DOI: 10.1371/journal.ppat.1002145

Cite This Page:

Montana State University. "Surprising condition occurs in lungs after an invasion of mold, study shows." ScienceDaily. ScienceDaily, 4 August 2011. <www.sciencedaily.com/releases/2011/08/110804124702.htm>.
Montana State University. (2011, August 4). Surprising condition occurs in lungs after an invasion of mold, study shows. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/08/110804124702.htm
Montana State University. "Surprising condition occurs in lungs after an invasion of mold, study shows." ScienceDaily. www.sciencedaily.com/releases/2011/08/110804124702.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins