Featured Research

from universities, journals, and other organizations

Researchers develop risk assessment model for advanced age-related macular degeneration

Date:
August 8, 2011
Source:
JAMA and Archives Journals
Summary:
A new risk assessment model may help predict development of advanced age-related macular degeneration, according to a new study.

A new risk assessment model may help predict development of advanced age-related macular degeneration, according to a report published Online First by Archives of Ophthalmology, one of the JAMA/Archives journals.

Age-related macular degeneration (AMD) is a leading cause of blindness in the United States and the Western world, according to background information in the article. "As progress in designing better preventive measures and earlier treatment options accelerates and new gene associations are identified that add to currently known risk factors, the desirability of having a reliable risk assessment model has become of considerable interest and potential value," write the authors. The model, they explain, should identify individuals with early AMD who are at greatest risk to progress to advanced AMD and should be able to predict when that progression might occur.

Michael L. Klein, M.D., from the Casey Eye Institute, Oregon Health & Science University, Portland, and colleagues sought to design a risk assessment model for development of advanced AMD that included phenotypic (related to observable physical characteristics), demographic, environmental and genetic risk factors. They used longitudinal data from the Age-Related Eye Disease Study, including participants' DNA samples, ocular and medical histories and examinations. The researchers identified two endpoints: development of advanced AMD in either eye by participants who did not have this condition at baseline, and advanced AMD in a second eye by participants who, at baseline, had it in one eye. Patients were followed for an average of 9.3 years.

The variables included in the final model included simple scale score (a sum of clinical risk factors in both eyes), two genotypes, very large drusen (deposits on the retina associated with AMD), smoking, family history, advanced AMD in one eye and age. The complete model appeared to perform well and to discriminate an individual's risk of advanced AMD. Of the 2,602 participants in the final model who, at baseline, had no advanced AMD, 24 percent (n = 635) developed advanced AMD during follow-up. Of those with advanced AMD at baseline, 82 percent who had the geographic atrophy (gradual deterioration of retinal cells, called "dry AMD") type and 56 percent who had the neovascular type (new blood vessel formation and leakage, called "wet AMD") developed advanced AMD in the other eye.

The results "can be of potential value in clinical practice by helping determine the frequency of follow-up examinations, the use of home monitoring of central vision, and the advisability of initiating preventive measures including beneficial lifestyle changes such as dietary alterations and nutritional supplement use," the authors note. "The short-term end points (e.g., 2 years) may be helpful in planning clinical trials." They add that the model performed well on measures of discrimination, calibration and overall performance. "We believe our current model is of substantial value in assessing AMD risk, and we expect that future advances will further improve its accuracy," they write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael L. Klein; Peter J. Francis; Frederick L. Ferris, III; Sara C. Hamon; Traci E. Clemons. Risk Assessment Model for Development of Advanced Age-Related Macular Degeneration. Archives of Ophthalmology, 2011; DOI: 10.1001/archophthalmol.2011.216

Cite This Page:

JAMA and Archives Journals. "Researchers develop risk assessment model for advanced age-related macular degeneration." ScienceDaily. ScienceDaily, 8 August 2011. <www.sciencedaily.com/releases/2011/08/110808161137.htm>.
JAMA and Archives Journals. (2011, August 8). Researchers develop risk assessment model for advanced age-related macular degeneration. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2011/08/110808161137.htm
JAMA and Archives Journals. "Researchers develop risk assessment model for advanced age-related macular degeneration." ScienceDaily. www.sciencedaily.com/releases/2011/08/110808161137.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins