Featured Research

from universities, journals, and other organizations

Metabolomics as a basis for gender-specific drugs

Date:
August 11, 2011
Source:
Public Library of Science
Summary:
Analyses of the metabolic profile of blood serum have revealed significant differences in metabolites between men and women. Scientists have concluded that there is a need for gender-specific therapies.

Analyses of the metabolic profile of blood serum have revealed significant differences in metabolites between men and women. In a study to be published on August 11 in the open-access journal PLoS Genetics, scientists at the Helmholtz Zentrum Mόnchen have concluded that there is a need for gender-specific therapies.

Gender-specific therapies may be required for some diseases as there are significant differences between male and female metabolism. Such differences were shown to exist for 101 of the 131 metabolites -- above all in lipid and amino acid species -- in the sera of more than 3,000 volunteers who took part in the population-based KORA study. Professor Thomas Illig and Dr. Kirstin Mittelstrass see this as proof that "in terms of molecular profiles, men and women have to be assigned to two completely different categories. That means that we also need gender-specific approaches to the treatment of diseases."

The researchers combined genetic data with metabolic profiles, which indicate the metabolic paths that are active given the specific conditions. The combination of genetics and metabolomics provides insight into the causes and progression of specific diseases. This could allow new therapeutic approaches and drugs to be developed, and enable markers to be found for the early recognition of diseases such as diabetes.

In the next phase, the scientists will increase the number of metabolites and evaluate further studies from a gender-specific point of view. "Through the combination of gender-specific evaluation, genetic association studies and metabolomics we will gain a detailed understanding of how major widespread diseases such as diabetes mellitus develop," Professor Illig says.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kirstin Mittelstrass, Janina S. Ried, Zhonghao Yu, Jan Krumsiek, Christian Gieger, Cornelia Prehn, Werner Roemisch-Margl, Alexey Polonikov, Annette Peters, Fabian J. Theis, Thomas Meitinger, Florian Kronenberg, Stephan Weidinger, Heinz Erich Wichmann, Karsten Suhre, Rui Wang-Sattler, Jerzy Adamski, Thomas Illig. Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers. PLoS Genetics, 2011; 7 (8): e1002215 DOI: 10.1371/journal.pgen.1002215

Cite This Page:

Public Library of Science. "Metabolomics as a basis for gender-specific drugs." ScienceDaily. ScienceDaily, 11 August 2011. <www.sciencedaily.com/releases/2011/08/110811181710.htm>.
Public Library of Science. (2011, August 11). Metabolomics as a basis for gender-specific drugs. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/08/110811181710.htm
Public Library of Science. "Metabolomics as a basis for gender-specific drugs." ScienceDaily. www.sciencedaily.com/releases/2011/08/110811181710.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins