Featured Research

from universities, journals, and other organizations

New risk score spots patients at high risk of serious blood clots

Date:
August 18, 2011
Source:
University of Nottingham
Summary:
A new risk prediction tool can identify patients at high risk of serious blood clots who might need preventative treatment, according to a new study.

A new risk prediction tool can identify patients at high risk of serious blood clots who might need preventative treatment, according to a study published in the British Medical Journal online.

Related Articles


The tool, which can be found at www.qthrombosis.org, is based on simple variables which the patient is likely to know and could be easily integrated into GP computer systems to risk assess patients prior to hospital admission, long haul flights, or starting medications that carry an increased clotting risk.

The condition, known as venous thromboembolism, is a common potentially lethal disease which can be prevented. In England alone, it claims more than 25,000 lives each year and, of those who survive, almost a third experience long-term effects.

In 2010, the National Institute for Health and Clinical Excellence (NICE) issued guidance to encourage the identification of high-risk patients and effective use of preventative measures. Yet there are no validated risk prevention algorithms suitable for use in primary care.

So researchers at The University of Nottingham set out to develop and validate a new clinical risk prediction algorithm (QThrombosis), designed to predict a person's risk of developing a potentially fatal clot.

Professor Julia Hippisley-Cox and Dr Carol Coupland, of the University's Division of Primary Care, used the QResearch database for the study (www.qresearch.org).

Using data from 563 general practices in England and Wales, they studied more than 3.5 million patients aged 25 to 84 years with no previous history of blood clots. First cases of venous thromboembolism -- either deep vein thrombosis or pulmonary embolism -- were identified from a patient's medical records or death certificate, at one year and five years.

The rate of venous thromboembolism was around 15 cases per 10,000 person years of observations.

They show that the risk of venous thromboembolism in both men and women increased with increasing age, body mass index and quantity of cigarettes smoked each day. Risks were also elevated among those with varicose veins, congestive heart failure, chronic kidney disease, chronic lung disease, inflammatory bowel disease, and any cancer.

Admission to hospital in the last six months also conferred a greater risk, as did taking antipsychotic drugs, oral contraceptives, HRT or tamoxifen.

The authors conclude: "We have developed and validated a new risk prediction model which identifies patients at high risk of venous thromboembolism. The algorithm is based on simple clinical variables which the patient is likely to know or which are routinely recorded in GP computer systems.

"The algorithm could be integrated into GP computer systems and used to risk assess patients prior to hospital admission or prior to the initiation of medication which might increase risk of venous thromboembolism."

They add: "Further research is needed to assess how best to use the algorithm and whether, upon implementation, it has any impact on health outcomes."


Story Source:

The above story is based on materials provided by University of Nottingham. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Hippisley-Cox, C. Coupland. Development and validation of risk prediction algorithm (QThrombosis) to estimate future risk of venous thromboembolism: prospective cohort study. BMJ, 2011; 343 (aug16 1): d4656 DOI: 10.1136/bmj.d4656

Cite This Page:

University of Nottingham. "New risk score spots patients at high risk of serious blood clots." ScienceDaily. ScienceDaily, 18 August 2011. <www.sciencedaily.com/releases/2011/08/110817075429.htm>.
University of Nottingham. (2011, August 18). New risk score spots patients at high risk of serious blood clots. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2011/08/110817075429.htm
University of Nottingham. "New risk score spots patients at high risk of serious blood clots." ScienceDaily. www.sciencedaily.com/releases/2011/08/110817075429.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins