Featured Research

from universities, journals, and other organizations

Single vaccines to protect against both rabies and Ebola

Date:
August 25, 2011
Source:
Thomas Jefferson University
Summary:
Researchers have developed single vaccines to protest against both rabies and the Ebola virus.

Researchers from Thomas Jefferson University, among other institutions, including the National Institute of Allergy and Infectious Diseases, have developed single vaccines to protest against both rabies and the Ebola virus.

Successfully tested in mice, these bivalent vaccines have several advantages over other Ebola candidates that could help speed up development for use in humans and primates. It's built on the same platform as the already approved and financially viable rabies vaccine, and it protects at-risk populations against two viruses, not just one, making it an effective and ideal public health tool.

"Many Ebola vaccine candidates have been proven effective, but none are close to licensure," said Matthias Schnell, Ph.D., director of the Jefferson Vaccine Center. "One of the challenges is the market: There's rather limited incentive in creating a vaccine for Ebola. But these vaccines could change that."

The findings were published ahead of print online August 17 in the Journal of Virology.

The Ebola virus belongs to the Filoviridae family and is composed of five distinct species. The Zaοre, Sudan and Bundibugyo species have been associated with large Ebola hemorrhagic fever outbreaks in Africa. According to the World Health Organization, more than a thousand people have died from the virus since it was discovered in 1976.

"Rabies still poses a health threat for people worldwide, and is especially devastating in developing nations where a post exposure treatment is often not available. And Ebola still exists in parts of Central Africa and is also a chief bioterrorism concern worldwide," said Dr. Schnell, who is also a Professor in the Department of Microbiology and Immunology at Thomas Jefferson University. "You can protect these people from two very lethal diseases in an area where they don't have the best access to medical care."

The purpose of this study was to identify novel vaccine candidates for Ebola with a maximum potential of licensure and utilization.

Researchers generated a chemically inactivated and live rabies virus expressing the Ebola Zaοre species glycoprotein using a reverse genetics system based on the commonly-used rabies vaccine. Immunizations with those vaccines, the researchers found, induced immunity against each virus and conferred protection from both viruses in mice.

Piggy backing, in a sense, on the rabies vaccine could accelerate development of vaccines that protects against Ebola because of the advanced state of the rabies vaccine's safety, production and distribution, according to Schnell.

"After the vaccine has been tested in primates and eventually humans, this new vaccine could kill the proverbially two birds with one stone," he said.

There are implications for non-humans, too -- gorillas, in particular. The Ebola virus has eradicated thousands of gorillas, prompting the World Conservation Union to raise their status to "critically endangered" in 2007, the first time a mammal has become critically endangered as a direct result of disease. Vaccinations, though challenging, could stall those deaths.

What's more, several human outbreaks have been attributed to primate interaction or handling, so providing a vaccine for our closest relative could minimize that risk.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. E. Blaney, C. Wirblich, A. B. Papaneri, R. F. Johnson, C. J. Myers, T. L. Juelich, M. R. Holbrook, A. N. Freiberg, J. G. Bernbaum, P. B. Jahrling, J. Paragas, M. J. Schnell. Inactivated or Live-Attenuated Bivalent Vaccines that Confer Protection against Rabies and Ebola Viruses. Journal of Virology, 2011; DOI: 10.1128/JVI.00558-11

Cite This Page:

Thomas Jefferson University. "Single vaccines to protect against both rabies and Ebola." ScienceDaily. ScienceDaily, 25 August 2011. <www.sciencedaily.com/releases/2011/08/110825154334.htm>.
Thomas Jefferson University. (2011, August 25). Single vaccines to protect against both rabies and Ebola. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2011/08/110825154334.htm
Thomas Jefferson University. "Single vaccines to protect against both rabies and Ebola." ScienceDaily. www.sciencedaily.com/releases/2011/08/110825154334.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) — A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) — The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins