Featured Research

from universities, journals, and other organizations

Study finds more gut reaction to arthritis drugs; Stomach acid-suppressing drugs appear to damage small intestine

Date:
September 2, 2011
Source:
McMaster University
Summary:
A research team has found stomach acid-reducing drugs, known as proton pump inhibitors, may actually be aggravating damage in the small intestine caused by nonsteroidal anti-inflammatory drugs, also known as NSAIDs.

Patients often take drugs to lower stomach acid and reduce the chances they will develop ulcers from taking their anti-inflammatory drugs for conditions such as arthritis, but the combination may be causing major problems for their small intestines, McMaster researchers have found.

Related Articles


A team from the Farncombe Family Digestive Health Research Institute has found those stomach acid-reducing drugs, known as proton pump inhibitors, may actually be aggravating damage in the small intestine caused by the nonsteroidal anti-inflammatory drugs, also known as NSAIDs.

In a study published in the medical journal Gastroenterology, principal investigator John Wallace says the extent of the hard-to-detect damage caused to the small intestine has only recently been discovered through use of small video cameras swallowed like pills.

"Suppressing acid secretion is effective for protecting the stomach from damage caused by NSAIDs, but these drugs appear to be shifting the damage from the stomach to the small intestine, where the ulcers may be more dangerous and more difficult to treat," said Wallace. He is director of the Farncombe institute and professor of medicine of the Michael G. DeGroote School of Medicine at McMaster.

He added that the use of probiotics is being investigated as a potential cure for the small intestine damage.

The study was funded by the Canadian Institutes of Health Research (CIHR) and a CIHR/Canadian Association of Gastroenterology Fellowship.


Story Source:

The above story is based on materials provided by McMaster University. Note: Materials may be edited for content and length.


Journal Reference:

  1. John L. Wallace, Stephanie Syer, Emmanuel Denou, Giada De Palma, Linda Vong, Webb McKnight, Jennifer Jury, Manlio Bolla, Premysl Bercik, Stephen M. Collins, Elena Verdu, Ennio Ongini. Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis. Gastroenterology, 2011; DOI: 10.1053/j.gastro.2011.06.075

Cite This Page:

McMaster University. "Study finds more gut reaction to arthritis drugs; Stomach acid-suppressing drugs appear to damage small intestine." ScienceDaily. ScienceDaily, 2 September 2011. <www.sciencedaily.com/releases/2011/09/110901155252.htm>.
McMaster University. (2011, September 2). Study finds more gut reaction to arthritis drugs; Stomach acid-suppressing drugs appear to damage small intestine. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2011/09/110901155252.htm
McMaster University. "Study finds more gut reaction to arthritis drugs; Stomach acid-suppressing drugs appear to damage small intestine." ScienceDaily. www.sciencedaily.com/releases/2011/09/110901155252.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins