Sep. 6, 2011 In several sub-Saharan African countries, the rapid, widespread implementation of insecticide treated nets (often referred to as ITNs -- which can prevent malaria by protecting those sleeping under them from the bites of night-flying, malaria parasite-carrying mosquitoes) has been accompanied by significant reductions in child deaths, real life findings that reflect the results of clinical trials and support continued efforts to scale-up and maintain ITN coverage in sub-Saharan Africa.
In a multi-country analysis led by Stephen Lim from the Institute for Health Metrics and Evaluation based in Seattle, USA, and published in this week's PLoS Medicine, the authors analyzed and combined data from 7 surveys in 7 sub-Saharan African countries to show that children living in a household that owned an ITN were 20% less likely to have malaria parasites in their blood (parasitemia). Importantly, the authors found a 23% reduction in child deaths (aged between 1 month and 5 years) associated with family ITN ownership based on 29 surveys in 22 sub-Saharan African countries. These findings support the widespread provision of ITNs as a key intervention in controlling malaria.
The authors say: "Our findings across a number of sub-Saharan African countries were highly consistent with results from previous clinical trials."
They continue: "These findings suggest that the recent scale-up in ITN coverage has likely been accompanied by significant reductions in child mortality and that additional health gains could be achieved with further increases in ITN coverage in populations at risk of malaria."
In an accompanying Perspective, Thomas Eisele from Tulane University School of Public Health and Tropical Medicine in New Orleans, USA and Richard Steketee from PATH in Seattle, USA say: "As Lim and colleagues suggest, continued scale-up of long-lasting ITNs must be a cornerstone of this effort and there are still lives to be saved with this intervention."
However, they highlight that as long-lasting ITNs typically wear out after 2-3 years, the malaria control community must attend to finding the most efficient means of replacing worn out nets once high coverage has been achieved. Eisele and Steketee conclude: "ITNs alone are insufficient to completely eliminate malaria transmission in areas of Africa suitable to perennial transmission. It is therefore imperative for the malaria community to apply its program experience and success with ITNs towards a focus on testing new tools and delivery approaches to achieve the next level of malaria transmission reduction beyond what is achievable by high ITN coverage alone."
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- Stephen S. Lim, Nancy Fullman, Andrew Stokes, Nirmala Ravishankar, Felix Masiye, Christopher J. L. Murray, Emmanuela Gakidou. Net Benefits: A Multicountry Analysis of Observational Data Examining Associations between Insecticide-Treated Mosquito Nets and Health Outcomes. PLoS Medicine, 2011; 8 (9): e1001091 DOI: 10.1371/journal.pmed.1001091
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