Featured Research

from universities, journals, and other organizations

First U.S. patient receives specially processed donor lungs; Possible new option to increase transplantable lung supply

Date:
September 8, 2011
Source:
University of Maryland Medical Center
Summary:
Surgeons have transplanted the first lungs treated in the United States with an experimental repair process before transplantation, to evaluate the efficacy of repairing lungs that might otherwise have been passed over as unsuitable for organ donation.

Surgeons at the University of Maryland Medical Center have transplanted the first lungs treated in the United States with an experimental repair process before transplantation. The procedure is part of a five-center national clinical research trial to evaluate the efficacy of repairing, before transplant, lungs that might otherwise have been passed over as unsuitable for organ donation. The results of this study, if successful, could significantly expand the number of transplantable lungs available to patients awaiting transplants.

Related Articles


Currently, only 15-20 percent of donor lungs are transplantable; most do not meet transplant criteria. The research focuses on an external perfusion technique using a fluid called STEEN Solution™ .

Over 1,700 people are on the lung transplant waiting list in the U.S., including nearly 30 in Maryland, according to the United Network for Organ Sharing.

"We are excited about the prospect of what this ex vivo, out-of-the-body perfusion technique could mean for our many transplant candidates who often spend years waiting for lungs to become available," says the principal investigator, Bartley P. Griffith, M.D., professor of surgery at the University of Maryland School of Medicine and chief of cardiothoracic surgery at the University of Maryland Medical Center. "This research is part of our ongoing goal to develop innovative procedures and rapidly improve our patients' quality of life."

Lungs in this clinical trial are recovered using current donor lung retrieval techniques. Once brought to the study transplant center, the lungs are re-assessed by the transplant team. The lungs are then physiologically assessed during ex vivo perfusion with STEEN Solution™ over a period of three to four hours. During this time, the transplant team evaluates abnormalities inside the lungs, oxygenation levels and overall health of the lungs. At the end of the process, the transplant team determines if the lungs meet the high standards necessary for transplantation.

"Our goal is to constantly advance science and medicine in order to better serve our patients," says E. Albert Reece, M.D., Ph.D., M.B.A., vice president of medical affairs at the University of Maryland and dean of the University of Maryland School of Medicine. "Clinical trials, such as this ex vivo lung perfusion, are an important tool to help us apply discovery from the laboratory to patient care at the bedside."

"Studies from other sites outside the U.S. have demonstrated that the results after transplantation using this ex vivo technique were at least as good as lungs that had not required perfusion," says Griffith. "These findings, plus the expertise from within our own center, give me great confidence in the future use of this ex vivo perfusion technique as an option to potentially increase our pool of transplantable lungs and reduce long wait times for our transplant candidates."

STEEN Solution™ is a product of Xvivo Perfusion, part of the Vitrolife Group, Goteborg, Sweden.


Story Source:

The above story is based on materials provided by University of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Maryland Medical Center. "First U.S. patient receives specially processed donor lungs; Possible new option to increase transplantable lung supply." ScienceDaily. ScienceDaily, 8 September 2011. <www.sciencedaily.com/releases/2011/09/110908091415.htm>.
University of Maryland Medical Center. (2011, September 8). First U.S. patient receives specially processed donor lungs; Possible new option to increase transplantable lung supply. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2011/09/110908091415.htm
University of Maryland Medical Center. "First U.S. patient receives specially processed donor lungs; Possible new option to increase transplantable lung supply." ScienceDaily. www.sciencedaily.com/releases/2011/09/110908091415.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins