Featured Research

from universities, journals, and other organizations

Body clock found to regulate platelet function

Date:
September 10, 2011
Source:
Brigham and Women's Hospital
Summary:
Researchers have demonstrated that the circadian system, the body's internal clock, regulates human platelet function and causes a peak in platelet activation corresponding to the known morning peak in adverse cardiovascular events.

Researchers at Brigham and Women's Hospital (BWH) have demonstrated that the circadian system, the body's internal clock, regulates human platelet function and causes a peak in platelet activation corresponding to the known morning peak in adverse cardiovascular events.

These findings are published in PLoS ONE on September 8, 2011.

"Cardiovascular disease is still the number one cause of death in developed countries, and we know major adverse cardiovascular events do not occur at random, but are more frequent in the morning," said lead author Frank Scheer, PhD, Assistant Professor of Medicine at the Division of Sleep Medicine at BWH. "Understanding the underlying factors for this morning peak in adverse events has the potential to address this pattern and decrease the risk."

In this study, the researchers demonstrated that the body clock regulates platelet function and causes a peak in platelet activation corresponding to the morning peak in adverse cardiovascular events such as myocardial infarction and stroke. A high level of platelet activation can lead to adverse cardiovascular events by influencing blood clotting. According to Scheer, this finding mimics the pattern of morning peaks in cardiovascular risk and tells us that platelet function is likely one of the factors that contributes to this morning peak in adverse cardiovascular events.

"Further study is required to test whether this circadian pattern in platelet activation, as demonstrated here in healthy subjects, is shifted in time or has different rhythm amplitude in people with cardiovascular disease," Scheer said.

The study used a forced desynchrony protocol during which required healthy young subjects to live on a 20-hour day for 12 cycles in a dim-light, time-free, and controlled environment. The design of this protocol allowed the isolation of the effect of the internal circadian timing system on platelet function, independent of effects of the sleep/wake cycle and other behavioral or environmental changes. Platelet function was assessed by flow cytometry and whole blood platelet aggregability.

Advancing the understanding of the underlying mechanisms for this morning peak is expected to have important clinical relevance. "We believe it's likely that there are many other factors that contribute to the peak in adverse cardiovascular events in the morning," said Dr. Scheer. "The next steps in addressing this issue are to further investigate control mechanisms involved in the circadian rhythm in platelet function, the role of the circadian system in other cardiovascular risk factors, and the changes in circadian control of cardiovascular risk factors in vulnerable populations."

The research was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Frank A. J. L. Scheer, Alan D. Michelson, Andrew L. Frelinger, Heather Evoniuk, Erin E. Kelly, Mary McCarthy, Lauren A. Doamekpor, Marc R. Barnard, Steven A. Shea. The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors. PLoS ONE, 2011; 6 (9): e24549 DOI: 10.1371/journal.pone.0024549

Cite This Page:

Brigham and Women's Hospital. "Body clock found to regulate platelet function." ScienceDaily. ScienceDaily, 10 September 2011. <www.sciencedaily.com/releases/2011/09/110909111447.htm>.
Brigham and Women's Hospital. (2011, September 10). Body clock found to regulate platelet function. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/09/110909111447.htm
Brigham and Women's Hospital. "Body clock found to regulate platelet function." ScienceDaily. www.sciencedaily.com/releases/2011/09/110909111447.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins