Featured Research

from universities, journals, and other organizations

Cell dysfunction linked to obesity and metabolic disorders

Date:
September 26, 2011
Source:
Karolinska Institutet
Summary:
By measuring the radioactive isotope carbon-14, scientists have revealed an association between lipid cell dysfunction and diseases such as obesity, diabetes and blood lipid disorders.

By measuring the radioactive isotope carbon-14, scientists at Karolinska Institutet have revealed an association between lipid cell dysfunction and diseases such as obesity, diabetes and blood lipid disorders.

Related Articles


The study, which is presented in the journal Nature, can lead to new approaches to combating metabolic diseases.

The results show that fat cells in overweight people have a higher capacity for storing fats but a lower capacity for ridding themselves of them.

"One might intuitively think that this was the case," says Peter Arner, who led the study together with Kirsty Spalding. "But this is the first time that someone has demonstrated that the metabolism of fat in the fat cells differs between healthy and obese individuals. This paves the way for new research fields and therapies that affect the storage and release of fat from fat cells."

The researchers used tissue samples from almost 100 people, ranging in weight from slim to massively obese. By ascertaining the age of the fat in the fat cells, they were able to draw conclusions on how the fat is stored and removed from the fat mass over time. The method for determining the age of the fat in fat cells is based on the incorporation of radioactive carbon-14 from the atmosphere into the body. Cold War nuclear testing caused a sharp increase in atmospheric carbon-14, which has gradually declined since testing stopped.

"We can use measurements of carbon-14 in fat against known levels of 14C in the atmosphere to date stamp the fat," says Dr Spalding, the developer of the method for examining fat tissue and other biological samples.

The researchers concluded that the fat stored in the fat cells of healthy people is renewed on average six times during the ten years of a fat-cell's lifespan. On the other hand, people with a preliminary stage of type II diabetes (insulin resistance) showed a reduced ability to rid their fat cells of fat.

This also applied to people with familial combined hyperlipidemia, a common form of congenital blood lipid disorder associated with a high risk of coronary artery disease. These people, however, also displayed a reduced ability to store fat in their fat cells. When the metabolism is upset in this way, it could mean that the concentration of triglycerides and cholesterol in the blood rises.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peter Arner, Samuel Bernard, Mehran Salehpour, Gφran Possnert, Jakob Liebl, Peter Steier, Bruce A. Buchholz, Mats Eriksson, Erik Arner, Hans Hauner, Thomas Skurk, Mikael Rydιn, Keith N. Frayn, Kirsty L. Spalding. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature, 2011; DOI: 10.1038/nature10426

Cite This Page:

Karolinska Institutet. "Cell dysfunction linked to obesity and metabolic disorders." ScienceDaily. ScienceDaily, 26 September 2011. <www.sciencedaily.com/releases/2011/09/110926081901.htm>.
Karolinska Institutet. (2011, September 26). Cell dysfunction linked to obesity and metabolic disorders. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2011/09/110926081901.htm
Karolinska Institutet. "Cell dysfunction linked to obesity and metabolic disorders." ScienceDaily. www.sciencedaily.com/releases/2011/09/110926081901.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins