Featured Research

from universities, journals, and other organizations

Modeling cancer using ecological principles

Date:
October 5, 2011
Source:
BioMed Central
Summary:
The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. New research uses the Tilman model of competition between invasive species to study the metastasis of prostate cells into bone.

The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. New research published in BioMed Central's open access journal Theoretical Biology and Medical Modelling uses the Tilman model of competition between invasive species to study the metastasis of prostate cells into bone.

Approximately 40,000 men a year in the US who have apparently successful surgery or radiotherapy for prostate cancer will suffer incurable metastasis of their disease in bone. The prostate cells invade the bone marrow and, sometimes after years of remaining dormant, compete with hematopoietic stem cells and take over the bone microenvironment.

The Tilman model examines various components of invasion of species into an environment. Kun-Wan Chen and Kenneth J. Pienta from the University of Michigan substituted steps in cancer progression into the Tilman equations. After initially multiplying and undergoing genetic mutation (equivalent to evolution) within the prostate, the cancer cells leave the prostate and enter the circulation. The next step is a period of survival in circulation followed by invasion into bone.

Once in the bone there is a 'lag period' while the cells establish themselves. Eventually, the cancer cells begin to multiply and out-compete the hematopoietic stem cells. Kun-Wan Chen explained, "The invading cancer cells could be thought of as several species, and the fittest mutants become dominant and multiply. Eventually there is a massive impact on the biosphere (human host)."

Prof Pienta continued, "Devastating ecological invasions are well known. For example introduction of domestic animals to Mauritius resulted in extinction of the dodo and Caulerpa taxifolia, a mutated killer algae, is plaguing the Mediterranean. Cancer metastasis follows a similar path to that of ecological invasions and our adaptation of the Tilman equations shows how invading cancer cells can destroy the normal body habitat. Use of ecological modeling can help us understand the complex biology of metastasis."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kun-Wan Chen and Kenneth J Pienta. Modeling invasion of metastasizing cancer cells to bone marrow utilizing ecological principles. Theoretical Biology and Medical Modelling (in press), 2011 [link]

Cite This Page:

BioMed Central. "Modeling cancer using ecological principles." ScienceDaily. ScienceDaily, 5 October 2011. <www.sciencedaily.com/releases/2011/10/111003080521.htm>.
BioMed Central. (2011, October 5). Modeling cancer using ecological principles. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2011/10/111003080521.htm
BioMed Central. "Modeling cancer using ecological principles." ScienceDaily. www.sciencedaily.com/releases/2011/10/111003080521.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins