Featured Research

from universities, journals, and other organizations

Smoking cigarettes simulates cystic fibrosis

Date:
October 13, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
If you smoke cigarettes, you have more in common with someone who has cystic fibrosis than you think. A new research report shows that smoking cigarettes affects the lungs in a way that is very similar to cystic fibrosis, a life threatening disease affecting the lungs and other organs.

If you smoke cigarettes, you have more in common with someone who has cystic fibrosis than you think. A new research report appearing online in the FASEB Journal shows that smoking cigarettes affects the lungs in a way that is very similar to cystic fibrosis, a life threatening disease affecting the lungs and other organs.

In cystic fibrosis, improper movement of salt and water in the cells lining the lungs causes a thick and sticky mucus to form. Bacteria become trapped in this mucus and thrive, leading to life-threatening lung infections. The FASEB Journal study shows that smoking negatively affects the lungs in a similar way, leading to mucus that causes dry cough, chronic bronchitis, and chronic obstructive pulmonary disease, among other problems.

"We hope this study will highlight the importance of airway hydration in terms of lung health and that it will help provide a road map for the development of novel therapies for the treatment of smoking-related lung disease," said Robert Tarran, Ph.D., a researcher involved in the work from the Cystic Fibrosis/Pulmonary Research and Treatment Center at the University of North Carolina at Chapel Hill.

To make this discovery, Tarran and colleagues conducted multiple experiments both in humans and in laboratory-grown cells testing the effects of cigarette smoke on the function of a protein that helps the lungs stay hydrated, called "CFTR." They found that people exposed to cigarette smoke had a 60 percent decrease in CFTR activity, compared to those exposed only to clean air. They also exposed human lung cells to either air or cigarette smoke and the measured the level of liquid covering the lung cells. The cells exposed to cigarette smoke had much lower liquid levels, which remained low for at least two and a half hours. Additional studies showed that this was caused by cigarette smoke interfering with CFTR's function. Finally, the researchers found that the addition of hypertonic saline -- a treatment for cystic fibrosis -- to cells exposed to cigarette smoke caused the level of liquid above the cells to increase toward normal levels. The hypertonic saline treatment also increased mucus clearance.

"This novel finding suggests that treatments aimed at cystic fibrosis might also help people with caused smoking-related diseases -- and vice versa," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "But the bottom line remains: the most effective treatment for smoker's cough, or worse, is to quit smoking, now! "


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. A. Clunes, C. M. Davies, R. D. Coakley, A. A. Aleksandrov, A. G. Henderson, K. L. Zeman, E. N. Worthington, M. Gentzsch, S. M. Kreda, D. Cholon, W. D. Bennett, J. R. Riordan, R. C. Boucher, R. Tarran. Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. The FASEB Journal, 2011; DOI: 10.1096/fj.11-192377

Cite This Page:

Federation of American Societies for Experimental Biology. "Smoking cigarettes simulates cystic fibrosis." ScienceDaily. ScienceDaily, 13 October 2011. <www.sciencedaily.com/releases/2011/10/111012113355.htm>.
Federation of American Societies for Experimental Biology. (2011, October 13). Smoking cigarettes simulates cystic fibrosis. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2011/10/111012113355.htm
Federation of American Societies for Experimental Biology. "Smoking cigarettes simulates cystic fibrosis." ScienceDaily. www.sciencedaily.com/releases/2011/10/111012113355.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins