Featured Research

from universities, journals, and other organizations

Smoking cigarettes simulates cystic fibrosis

Date:
October 13, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
If you smoke cigarettes, you have more in common with someone who has cystic fibrosis than you think. A new research report shows that smoking cigarettes affects the lungs in a way that is very similar to cystic fibrosis, a life threatening disease affecting the lungs and other organs.

If you smoke cigarettes, you have more in common with someone who has cystic fibrosis than you think. A new research report appearing online in the FASEB Journal shows that smoking cigarettes affects the lungs in a way that is very similar to cystic fibrosis, a life threatening disease affecting the lungs and other organs.

Related Articles


In cystic fibrosis, improper movement of salt and water in the cells lining the lungs causes a thick and sticky mucus to form. Bacteria become trapped in this mucus and thrive, leading to life-threatening lung infections. The FASEB Journal study shows that smoking negatively affects the lungs in a similar way, leading to mucus that causes dry cough, chronic bronchitis, and chronic obstructive pulmonary disease, among other problems.

"We hope this study will highlight the importance of airway hydration in terms of lung health and that it will help provide a road map for the development of novel therapies for the treatment of smoking-related lung disease," said Robert Tarran, Ph.D., a researcher involved in the work from the Cystic Fibrosis/Pulmonary Research and Treatment Center at the University of North Carolina at Chapel Hill.

To make this discovery, Tarran and colleagues conducted multiple experiments both in humans and in laboratory-grown cells testing the effects of cigarette smoke on the function of a protein that helps the lungs stay hydrated, called "CFTR." They found that people exposed to cigarette smoke had a 60 percent decrease in CFTR activity, compared to those exposed only to clean air. They also exposed human lung cells to either air or cigarette smoke and the measured the level of liquid covering the lung cells. The cells exposed to cigarette smoke had much lower liquid levels, which remained low for at least two and a half hours. Additional studies showed that this was caused by cigarette smoke interfering with CFTR's function. Finally, the researchers found that the addition of hypertonic saline -- a treatment for cystic fibrosis -- to cells exposed to cigarette smoke caused the level of liquid above the cells to increase toward normal levels. The hypertonic saline treatment also increased mucus clearance.

"This novel finding suggests that treatments aimed at cystic fibrosis might also help people with caused smoking-related diseases -- and vice versa," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "But the bottom line remains: the most effective treatment for smoker's cough, or worse, is to quit smoking, now! "


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. A. Clunes, C. M. Davies, R. D. Coakley, A. A. Aleksandrov, A. G. Henderson, K. L. Zeman, E. N. Worthington, M. Gentzsch, S. M. Kreda, D. Cholon, W. D. Bennett, J. R. Riordan, R. C. Boucher, R. Tarran. Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. The FASEB Journal, 2011; DOI: 10.1096/fj.11-192377

Cite This Page:

Federation of American Societies for Experimental Biology. "Smoking cigarettes simulates cystic fibrosis." ScienceDaily. ScienceDaily, 13 October 2011. <www.sciencedaily.com/releases/2011/10/111012113355.htm>.
Federation of American Societies for Experimental Biology. (2011, October 13). Smoking cigarettes simulates cystic fibrosis. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2011/10/111012113355.htm
Federation of American Societies for Experimental Biology. "Smoking cigarettes simulates cystic fibrosis." ScienceDaily. www.sciencedaily.com/releases/2011/10/111012113355.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins