Featured Research

from universities, journals, and other organizations

You are what you eat: Low fat diet with fish oil slows growth of human prostate cancer cells, study suggests

Date:
October 26, 2011
Source:
University of California - Los Angeles Health Sciences
Summary:
A low-fat diet with fish oil supplements eaten for four to six weeks prior to prostate removal slowed down the growth of prostate cancer cells -- the number of rapidly dividing cells -- in human prostate cancer tissue compared to a traditional, high-fat Western diet, according to a new study.

Men who ate a low-fat diet with fish oil supplements for four to six weeks before having their prostate removed had slower cancer-cell growth in their prostate tissue than men who ate a traditional, high-fat Western diet, according to a study by researchers at UCLA's Jonsson Comprehensive Cancer Center.

The researchers also found a change in the composition of cell membranes in both healthy cells and cancer cells in the prostates of men on the low-fat, fish oil-supplement diet. The membranes had heightened levels of omega-3 fatty acids from fish oil and decreased levels of omega-6 fatty acids from corn oil, which may directly affect the biology of the cells, though further studies are needed, said Dr. William Aronson, the study's first author and a researcher with the Jonsson Cancer Center.

The short-term study also found that blood obtained from patients after the low-fat, fish oil diet slowed the growth of prostate cancer cells in a test tube, while blood from men on the Western diet did not slow cancer growth.

"The finding that the low-fat, fish oil diet reduced the number of rapidly dividing cells in the prostate cancer tissue is important because the rate at which the cells are dividing can be predictive of future cancer progression," Aronson said. "The lower the rate of proliferation, the lesser the chances that the cancer will spread outside the prostate, where it is much harder to treat."

The findings are published Oct. 25 in Cancer Prevention Research, a peer-reviewed journal of the American Association for Cancer Research.

The study, which evaluated blood samples before and after the diet began and examined tissue from removed prostates, validated previous studies Aronson and others had done on cell lines and in animal models. Aronson said using human blood and tissue in this study proved that the changes prompted by what the men were eating were clearly evident in their prostate tissue -- that the "treatment" was indeed reaching the targeted organ because of the changes in the prostate cell membranes' fatty acid composition.

"You truly are what you eat," said Aronson, a clinical professor of urology who also serves as chief of urologic oncology at the West Los Angeles Veterans Affairs Medical Center. "Based on our animal studies, we were hopeful that we would see the same effects in humans. We are extremely pleased about our findings, which suggest that by altering the diet, we may favorably affect the biology of prostate cancer."

Aronson measured proliferation -- the rate of prostate cancer cell division -- by staining tissue obtained from the radical prostatectomy specimens with an antibody against Ki-67, a protein involved in the cell-cycle progression and growth.

"The percentage of prostate cancer cells that stained for Ki-67 was determined by the pathologist, and this gave us an objective measurement of the percentage of cells that were actively dividing and therefore more aggressive," Aronson said. "Previous studies found that patients with higher levels of Ki-67 in their prostate cancer tissue were more likely to have their prostate cancer progress to advanced stages and were more likely to die from their prostate cancer. Thus, we are extremely encouraged by our findings that a low-fat diet with fish oil lowered Ki-67 levels and may have the potential to slow the progression of prostate cancer."

Diet studies often are difficult to evaluate because getting patients to comply with dietary changes can be challenging. However, the food eaten by men in both arms of this study was precisely controlled, Aronson said. The meals were prepared by chefs at the UCLA Clinical Translational Research Center and delivered in bulk to study participants several times a week. Participants also met with a dietician, kept food diaries and were required to return uneaten food.

"The key to this study was having the meals prepared and delivered to the study participants," Aronson said. "This resulted in a very high rate of compliance, making the study very well controlled."

With the study's Western diet, 40 percent of the calories came from fat, which is generally equivalent to what many Americans consume today. The fat sources also were typical of the American diet and included high levels of omega-6 fatty acids from corn oil and low levels of fish oil that provides omega-3 fatty acids.

With the low-fat diet, 15 percent of the calories from fat. Additionally, the men on this diet took five grams of fish oil per day in five capsules, three with breakfast and two with dinner, to provide omega-3 fatty acids. Omega-3 fatty acids have been found to reduce the incidence of heart disease and to fight inflammation, which has been associated with certain cancers.

"Preclinical studies suggest that lowering dietary omega-6 fatty acids from corn oil and increasing omega-3 fatty acids from fish oil decreases the risk of prostate cancer development and progression," the study states. "We found this diet intervention resulted in a decrease in omega-6 vs. omega-3 fatty acid ratios in benign and malignant prostate tissue and a decrease in malignant cell proliferation."

Aronson cautioned that he could not recommend dietary changes based on this study, which included 48 men, because of its short duration and small sample size. However, based on these results, he is organizing a much larger study of 100 men with prostate cancers who have elected active surveillance, meaning they're not getting any treatment for their disease but are getting regular biopsies and check-ups.

The future study will randomly divide the men into a low-fat, fish oil-supplement group and a traditional Western diet group and follow them for a year to evaluate the diets' effects on prostate cancer proliferation.

This study was funded in part by the National Cancer Institute, the Department of Veterans Affairs and the Ruby Family Foundation.


Story Source:

The above story is based on materials provided by University of California - Los Angeles Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. William J. Aronson, Naoko Kobayashi, R. James Barnard, Susanne Henning, Min Huang, Patricia M. Jardack, Bingrong Liu, Ashley Gray, Junxiang Wan, Ramdev Konijeti, Stephen J. Freedland, Brandon Castor, David Heber, David Elashoff, Jonathan Said, Pinchas Cohen, Colette Galet. Phase II Prospective Randomized Trial of a Low-Fat Diet with Fish Oil Supplementation in Men Undergoing Radical Prostatectomy. Cancer Prevention Research, Published online Oct. 25, 2011; DOI: 10.1158/1940-6207.CAPR-11-0298

Cite This Page:

University of California - Los Angeles Health Sciences. "You are what you eat: Low fat diet with fish oil slows growth of human prostate cancer cells, study suggests." ScienceDaily. ScienceDaily, 26 October 2011. <www.sciencedaily.com/releases/2011/10/111025135931.htm>.
University of California - Los Angeles Health Sciences. (2011, October 26). You are what you eat: Low fat diet with fish oil slows growth of human prostate cancer cells, study suggests. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2011/10/111025135931.htm
University of California - Los Angeles Health Sciences. "You are what you eat: Low fat diet with fish oil slows growth of human prostate cancer cells, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/10/111025135931.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins