Featured Research

from universities, journals, and other organizations

Key element of cell division: How daughter cells receive the same number of chromosomes

Date:
November 1, 2011
Source:
University of Warwick
Summary:
Scientists have uncovered the molecular process of how cells are bypassing the body's inbuilt "health checkpoint" with unequal numbers of chromosomes that have a higher risk of developing cancer.

Scientists at Warwick Medical School have uncovered the molecular process of how cells are by-passing the body's inbuilt 'health checkpoint' with cells that carry unequal numbers of chromosomes that have a higher risk of developing cancer.

Related Articles


Studying simple yeast cells, scientists now understand the mechanism by which cells ensure their daughter cells receive the correct number of chromosomes.

Most cells in our bodies contain 23 pairs of chromosomes that encode our individual genetic identities. In healthy, dividing human cells, each of these chromosomes is duplicated and one copy passed to each of the two daughter cells. However, if this process is disturbed, daughter cells receive an unequal number of chromosomes, a state that is known to drive normal cells to become cancerous. In fact, aggressive human tumours are frequently composed of cells with an abnormal complement of chromosomes.

Professor Jonathan Millar explained: "This cell division process is monitored by the body's surveillance system known as the 'spindle checkpoint', and that is only switched off once everything within the cell is set up correctly. Amazingly, all of the elements of this process are conserved from yeast to human cells.

"Therefore it is extremely likely that what we have found in yeast also happens in human cells. So by preventing this process happening with drugs, you could restrict the cell's ability to develop into full blown cancer," explained Professor Millar.

Currently, one of the most frequently used classes of anti-cancer drugs are taxanes, which target the mitotic apparatus in part by preventing proper silencing of the spindle checkpoint. However, this class of drug affects healthy and cancerous cells alike and can have debilitating side effects including permanent neurological damage and hair loss.

Professor Millar said: "Now that we have pinpointed the central elements of cell division, we are in a great position to design drugs that can be more selective and targeted about which cells they treat. But this is just the start -- much more research has to be done before we can convert this into a commercial treatment for patients, but we are greatly encouraged that our research here at Warwick is leading the way in the search for more effective cancer treatments with fewer side effects."


Story Source:

The above story is based on materials provided by University of Warwick. Note: Materials may be edited for content and length.


Journal Reference:

  1. JohnC. Meadows, LindseyA. Shepperd, Vincent Vanoosthuyse, TheresaC. Lancaster, AlicjaM. Sochaj, GrahamJ. Buttrick, KevinG. Hardwick, JonathanB.A. Millar. Spindle Checkpoint Silencing Requires Association of PP1 to Both Spc7 and Kinesin-8 Motors. Developmental Cell, 2011; 20 (6): 739 DOI: 10.1016/j.devcel.2011.05.008

Cite This Page:

University of Warwick. "Key element of cell division: How daughter cells receive the same number of chromosomes." ScienceDaily. ScienceDaily, 1 November 2011. <www.sciencedaily.com/releases/2011/11/111101125947.htm>.
University of Warwick. (2011, November 1). Key element of cell division: How daughter cells receive the same number of chromosomes. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2011/11/111101125947.htm
University of Warwick. "Key element of cell division: How daughter cells receive the same number of chromosomes." ScienceDaily. www.sciencedaily.com/releases/2011/11/111101125947.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins