Featured Research

from universities, journals, and other organizations

Workings of molecular motor revealed

Date:
November 2, 2011
Source:
University of Oxford
Summary:
The structure and function of a 'molecular motor' critical to the functioning of human organs and, when malfunctioning, implicated in cancer, kidney failure, and osteoporosis, has been revealed in unprecedented detail.

Ball-and-stick model of adenosine triphosphate (ATP).
Credit: Ben Mills via Wikimedia Commons, public domain.

The structure and function of a 'molecular motor' critical to the functioning of human organs and, when malfunctioning, implicated in cancer, kidney failure, and osteoporosis, has been revealed in unprecedented detail.

Related Articles


An international team, led by chemists from Oxford University, has used highly sensitive mass-spectrometry to piece together a picture of how the motor, the energy-converting protein adenosine triphosphate (ATP) synthase, interacts with the fatty acids that form the membranes around our cells.

The team publish a report of the research in this week's Science.

'ATP synthase is found in every cell in our bodies and generates the energy necessary to keep our organs working,' said Professor Carol Robinson of Oxford University's Department of Chemistry, an author of the paper. 'Our team were able to effectively 'weigh' this molecular motor and calculate the exact weight of the fatty acids -- that act rather like a 'lubricant' for the motor -- that are attached to it.'

The researchers probed ATP synthase and its various component parts by stimulating it with high pH and different levels of ATP and Adenosine diphosphate (ADP). They were then able to watch how the different parts of this molecular motor responded and interacted in the kind of detail nobody has seen before

The team believe their discovery will be extremely important for future research into a wide range of diseases in which defects in such energy-converting machinery plays a part.

Professor Robinson said: 'Overall this research has not only contributed to our understanding of this cellular motor but also highlights opportunities to explore the effects of inhibitors that could one day help in the treatment of many conditions.'

.


Story Source:

The above story is based on materials provided by University of Oxford. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Zhou, N. Morgner, N. P. Barrera, A. Politis, S. C. Isaacson, D. Matak-Vinkovic, T. Murata, R. A. Bernal, D. Stock, C. V. Robinson. Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding. Science, 2011; 334 (6054): 380 DOI: 10.1126/science.1210148

Cite This Page:

University of Oxford. "Workings of molecular motor revealed." ScienceDaily. ScienceDaily, 2 November 2011. <www.sciencedaily.com/releases/2011/11/111101223107.htm>.
University of Oxford. (2011, November 2). Workings of molecular motor revealed. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2011/11/111101223107.htm
University of Oxford. "Workings of molecular motor revealed." ScienceDaily. www.sciencedaily.com/releases/2011/11/111101223107.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins