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Acid reflux drug does not improve asthma in children, study finds

Date:
January 24, 2012
Source:
Johns Hopkins Bloomberg School of Public Health
Summary:
A randomized clinic trial found that the addition of lansoprazole does not improve asthma symptoms or the control of asthma in children and may increase the risk for upper respiratory infections and other adverse events.

Asthma and gastroesophageal reflux (GER) are both common illnesses in children. GER in children often occurs without the typical symptoms of heartburn, and physicians frequently prescribe the acid reflux drug lansoprazole to supplement the standard inhaled steroid treatment for children with uncontrolled asthma regardless of GER symptoms. However, a randomized clinic trial conducted by the American Lung Association's Asthma Clinical Group found that the addition of lansoprazole does not improve asthma symptoms or the control of asthma in children and may increase the risk for upper respiratory infections and other adverse events.

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Results of the study appear in the January 25 issue of JAMA.

Lansoprazole belongs to a class of drugs called proton pump inhibitors (PPIs) that reduce acid in the stomach. Use of these drugs, including for the treatment of asthma symptoms, has risen dramatically in children over the last decade.

"The data were very clear. Lansoprazole did not improve asthma symptoms in children as compared to a placebo, and there is no evidence to support prescribing these drugs to treat asthma in children," said Janet Holbrook, PhD, corresponding author of the study and associate professor in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. "In our study, children taking lansoprazole showed an increased risk for respiratory infection, sore throats and bronchitis." The Bloomberg School's Center for Clinical Trials served as data coordinating center for the research team.

For the study, researchers from 18 trial sites studied 306 children ages 6 to 17 years. All study participants had inadequately controlled asthma despite taking inhaled corticosteroids but did not have the typical symptoms of GER.

Approximately 40 percent of participants were identified as having GER based on diagnostic testing. The participants were randomly selected to receive either a daily dose of lansoprazole or a placebo pill over a 24-week period in addition to their inhaled steroid therapy.

The researchers found no significant differences in severity of asthma symptoms or overall lung function between the group taking lansoprazole and the group receiving the placebo, including in the children positively identified as having GER. An earlier separate study of adults conducted by the same research team showed similar results.

The study was funded by the National Heart, Lung, and Blood Institute (NHLBI), which is part of the National Institutes of Health.


Story Source:

The above story is based on materials provided by Johns Hopkins Bloomberg School of Public Health. Note: Materials may be edited for content and length.


Journal References:

  1. J. T. Holbrook, R. A. Wise, B. D. Gold, K. Blake, E. D. Brown, M. Castro, A. J. Dozor, J. J. Lima, J. G. Mastronarde, M. M. Sockrider, W. G. Teague. Lansoprazole for Children With Poorly Controlled Asthma: A Randomized Controlled Trial. JAMA: The Journal of the American Medical Association, 2012; 307 (4): 373 DOI: 10.1001/jama.2011.2035
  2. F. D. Martinez. Children, Asthma, and Proton Pump Inhibitors: Costs and Perils of Therapeutic Creep. JAMA: The Journal of the American Medical Association, 2012; 307 (4): 406 DOI: 10.1001/jama.2012.33

Cite This Page:

Johns Hopkins Bloomberg School of Public Health. "Acid reflux drug does not improve asthma in children, study finds." ScienceDaily. ScienceDaily, 24 January 2012. <www.sciencedaily.com/releases/2012/01/120124162311.htm>.
Johns Hopkins Bloomberg School of Public Health. (2012, January 24). Acid reflux drug does not improve asthma in children, study finds. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2012/01/120124162311.htm
Johns Hopkins Bloomberg School of Public Health. "Acid reflux drug does not improve asthma in children, study finds." ScienceDaily. www.sciencedaily.com/releases/2012/01/120124162311.htm (accessed October 24, 2014).

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Treatment of Silent Acid Reflux Does Not Improve Asthma in Children, Study Finds

Jan. 24, 2012 Adding the acid reflux drug lansoprazole to a standard inhaled steroid treatment for asthma does not improve asthma control in children who have no symptom of acid reflux, according to a new study. ... read more

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