Featured Research

from universities, journals, and other organizations

Zebrafish may hold key to repairing serious eye conditions

Date:
February 14, 2012
Source:
University of Michigan Health System
Summary:
Researchers have taken an important step in understanding retina regeneration, suggesting new possibilities for developing treatments in humans.

An illustration shows HB-EGF's influence on retina regeneration.
Credit: Image courtesy of University of Michigan Health System

University of Michigan Health System research into the mechanisms by which zebrafish are able to regenerate damaged retinas after injury suggests new strategies for one day being able to do the same in humans -- potentially allowing doctors to slow or reverse conditions like macular degeneration and glaucoma.

Building on previous studies, Daniel Goldman, Ph.D., a professor at U-M's Molecular and Behavioral Neuroscience Institute and in the Department of Biological Chemistry, along with postdoctoral fellows Jin Wan and Rajesh Ramachandran, discovered that heparin-binding epidermal-like growth factor (HB-EGF) plays a critical role during retina regeneration. Their findings were recently published in Developmental Cell.

"We found that this factor is sufficient to activate the whole process," says Goldman.

When a zebrafish's retina is damaged, HB-EGF is released and sets in motion a series of changes that cause certain cells in the retina known as Muller glia to revert to a stem-cell state from which they can generate new cells and repair the damage. The researchers found that HB-EGF stimulated Muller glia to revert to a stem cell even in fish with uninjured eyes.

The next step, says Goldman, will be to explore if this factor and related pathways can stimulate Muller glia dedifferentiation and stem cell formation in mammals.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jin Wan, Rajesh Ramachandran, Daniel Goldman. HB-EGF Is Necessary and Sufficient for Mόller Glia Dedifferentiation and Retina Regeneration. Developmental Cell, 2012; 22 (2): 334 DOI: 10.1016/j.devcel.2011.11.020

Cite This Page:

University of Michigan Health System. "Zebrafish may hold key to repairing serious eye conditions." ScienceDaily. ScienceDaily, 14 February 2012. <www.sciencedaily.com/releases/2012/02/120214170957.htm>.
University of Michigan Health System. (2012, February 14). Zebrafish may hold key to repairing serious eye conditions. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/02/120214170957.htm
University of Michigan Health System. "Zebrafish may hold key to repairing serious eye conditions." ScienceDaily. www.sciencedaily.com/releases/2012/02/120214170957.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins