Featured Research

from universities, journals, and other organizations

Circadian clock governs highs and lows of immune response

Date:
February 16, 2012
Source:
Cell Press
Summary:
It's been said that timing is everything, and that may be particularly true when it comes to the ability to fight off disease. New research shows that the success of host immune defense depends in part on an organism's "body clock." The study may lead to therapeutic strategies designed to optimize the immune response and to protect patients at the time when they are most vulnerable.

It's been said that timing is everything, and that may be particularly true when it comes to the ability to fight off disease. New research published in the February issue of the journal Immunity shows that the success of host immune defense depends in part on an organism's "body clock." The study may lead to therapeutic strategies designed to optimize the immune response and to protect patients at the time when they are most vulnerable.

Many organisms have evolved an endogenous timing system called a circadian clock that regulates a wide variety of metabolic activities over a twenty-four hour cycle. "It is becoming increasingly evident that disruption of daily rhythms, such as from sleep deprivation, affects the immune response," explains senior study author, Dr. Erol Fikrig from Yale University School of Medicine. "In our study, we were interested in investigating whether the ability of the immune system to detect a pathogen is under circadian control and whether there are timing-associated consequences for the subsequent immune response."

Dr. Fikrig and colleagues examined the expression and function of Toll-like receptor 9 (TLR9), an immune system protein that can sense bacterial and viral DNA. The researchers demonstrated that the circadian clock controlled TLR9 expression and function and that mice immunized when TLR9 was most responsive exhibited an enhanced immune response. Importantly, in a mouse model of sepsis, disease severity was dependent on the timing of sepsis induction, which directly correlated with cyclical changes in TLR9. The authors suggest that this observation may be clinically significant as septic human patients are known to be at increased risk of mortality between 2 and 6 am.

"These findings not only unveil a novel, direct molecular link between circadian rhythms and the immune system, but also open a new paradigm in the biology of the overall immune response with important implications for the prevention and treatment of disease," concludes Dr. Fikrig. "Furthermore, patients in the ICU often have disturbed sleep patterns, due to noise, nocturnal light exposure and medications; it will be important to investigate how these factors influence TLR9 expression levels and immune responses."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Adam C. Silver, Alvaro Arjona, Wendy E. Walker, Erol Fikrig. The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity. Immunity, 2012 DOI: 10.1016/j.immuni.2011.12.017

Cite This Page:

Cell Press. "Circadian clock governs highs and lows of immune response." ScienceDaily. ScienceDaily, 16 February 2012. <www.sciencedaily.com/releases/2012/02/120216133430.htm>.
Cell Press. (2012, February 16). Circadian clock governs highs and lows of immune response. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2012/02/120216133430.htm
Cell Press. "Circadian clock governs highs and lows of immune response." ScienceDaily. www.sciencedaily.com/releases/2012/02/120216133430.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins