Featured Research

from universities, journals, and other organizations

New way to tap largest remaining treasure trove of potential new antibiotics

Date:
February 22, 2012
Source:
American Chemical Society
Summary:
Scientists are reporting use of a new technology for sifting through the world's largest remaining pool of potential antibiotics to discover two new antibiotics that work against deadly resistant microbes, including the "superbugs" known as MRSA.

Scientists are reporting use of a new technology for sifting through the world's largest remaining pool of potential antibiotics to discover two new antibiotics that work against deadly resistant microbes, including the "super bugs" known as MRSA.

Related Articles


Their report appears in the Journal of the American Chemical Society.

Sean Brady and colleagues explain that an urgent need exists for new medications to cope with microbes that shrug off the most powerful traditional antibiotics. Methicillin-resistant Staphylococcus aureus (MRSA) infections, for instance, are resistant to most known antibiotics. MRSA strikes at least 280,000 people in the U.S. alone every year, and almost 20,000 of those patients die. The typical way of discovering new antibiotics involves identifying and growing new bacteria from soil and other environmental samples in culture dishes in the laboratory. That environmental treasure-trove is the largest remaining potential source of new antibiotics. Researchers then analyze the bacteria to see if they make substances that could be used as antibiotics to kill other microbes. But most bacteria found in nature can't grow in the laboratory. That's why Brady and colleagues took a new approach to this problem.

The researchers removed DNA from soil bacteria that wouldn't grow in the lab. Then, they put this DNA into different bacteria that do grow well in culture dishes, and these bacteria acted like incubators for the new DNA. The approach enabled Brady's team to study the substances made by the soil bacteria's DNA in the lab. With this "metagenomics" method, they identified two new possible antibiotics called fasamycin A and fasamycin B that killed MRSA and vancomycin-resistant Enterococcus faecalis, which also is becoming more resistant to known antibiotics. They also determined how the new antibiotics work. "Metagenomics has the potential to access large numbers of previously inaccessible natural antibiotics," say the researchers.

The researchers acknowledge funding from the National Institutes of Health and the Howard Hughes Medical Institute.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zhiyang Feng, Debjani Chakraborty, Scott B. Dewell, Boojala Vijay B. Reddy, Sean F. Brady. Environmental DNA-Encoded Antibiotics Fasamycins A and B Inhibit FabF in Type II Fatty Acid Biosynthesis. Journal of the American Chemical Society, 2012; 134 (6): 2981 DOI: 10.1021/ja207662w

Cite This Page:

American Chemical Society. "New way to tap largest remaining treasure trove of potential new antibiotics." ScienceDaily. ScienceDaily, 22 February 2012. <www.sciencedaily.com/releases/2012/02/120222132938.htm>.
American Chemical Society. (2012, February 22). New way to tap largest remaining treasure trove of potential new antibiotics. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2012/02/120222132938.htm
American Chemical Society. "New way to tap largest remaining treasure trove of potential new antibiotics." ScienceDaily. www.sciencedaily.com/releases/2012/02/120222132938.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Your Complicated Job Might Keep Your Brain Young

Your Complicated Job Might Keep Your Brain Young

Newsy (Nov. 20, 2014) Researchers at the University of Edinburgh found the more complex your job is, the sharper your cognitive skills will likely be as you age. Video provided by Newsy
Powered by NewsLook.com
Mysterious Glow Worms Found in the Amazon

Mysterious Glow Worms Found in the Amazon

Buzz60 (Nov. 20, 2014) Wildlife photographer Jeff Cremer teamed up with entomologist Aaron Pomerantz and others to investigate a predatory glow worm found in the Amazon. Patrick Jones (@Patrick_E_Jones) explains. Video provided by Buzz60
Powered by NewsLook.com
Raw: Huge Snow Covers Buffalo Streets

Raw: Huge Snow Covers Buffalo Streets

AP (Nov. 20, 2014) A new blast of lake-effect snow roared through western New York with thunder and lightning on Thursday, raising to nearly 6 feet the three-day total in parts of the Buffalo area. (Nov. 20) Video provided by AP
Powered by NewsLook.com
Report Warns of Global Chocolate Shortage

Report Warns of Global Chocolate Shortage

Buzz60 (Nov. 20, 2014) A new report warns the world could face a 2.2-billion pound chocolate shortage within the next five years. Mike Janela (@mikejanela) explains. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins