Featured Research

from universities, journals, and other organizations

No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity

Date:
February 29, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
If you want big muscles without working out, there's hope. Scientists report a family of protein transcription factors, called "Forkhead (Fox0)," that plays a significant role in the regulation of skeletal muscle mass. Interfering with Fox0 prevented muscle wasting associated with cancer and sepsis, and even promoted muscle growth. This is likely relevant to any disease, condition or lifestyle that leads to muscle wasting.

If you want big muscles without working out, there's hope. In the March 2012 print issue of the FASEB Journal, scientists from the University of Florida report that a family of protein transcription factors, called "Forkhead (Fox0)" plays a significant role in the regulation of skeletal muscle mass. Specifically, they found that interfering with the activity of these transcription factors prevents muscle wasting associated with cancer and sepsis, and even promotes muscle growth. This discovery is likely to be relevant to any disease, condition or lifestyle that leads to muscle wasting, including voluntary inactivity.

"The loss of muscle mass is a major contributor to disease-related deaths," said Andrew R. Judge, Ph.D., a researcher involved in the work from the Department of Physical Therapy at the University of Florida in Gainesville. "FoxO proteins may provide a target for therapies aimed at reducing muscle wasting and thus improving the quality of life and survival rates for patients with many different diseases."

To make this discovery, Judge and colleagues genetically inhibited the activity of "Forkhead boxO" proteins, or "FoxO," in the skeletal muscle of healthy control mice, septic mice, and mice with cancer. The loss of muscle mass in those with cancer and sepsis was significantly decreased by inhibition of FoxO activity. In healthy control animals inhibiting FoxO activity caused an increase in muscle cell size which occurred as a result of protein synthesis.

"No one can deny that the human body was meant to move, and to move often," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "but the reality is that many of us don't move enough, whether because of disease, injury, or simply a busy schedule. This discovery is another important step towards the treatment of muscle wasting in cancer, severe infection or aging -- or to maintain our muscle mass to help face the slings and arrows of outrageous fortune."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. A. Reed, P. B. Sandesara, S. M. Senf, A. R. Judge. Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy. The FASEB Journal, 2011; 26 (3): 987 DOI: 10.1096/fj.11-189977

Cite This Page:

Federation of American Societies for Experimental Biology. "No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity." ScienceDaily. ScienceDaily, 29 February 2012. <www.sciencedaily.com/releases/2012/02/120229105135.htm>.
Federation of American Societies for Experimental Biology. (2012, February 29). No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2012/02/120229105135.htm
Federation of American Societies for Experimental Biology. "No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity." ScienceDaily. www.sciencedaily.com/releases/2012/02/120229105135.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins