Featured Research

from universities, journals, and other organizations

No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity

Date:
February 29, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
If you want big muscles without working out, there's hope. Scientists report a family of protein transcription factors, called "Forkhead (Fox0)," that plays a significant role in the regulation of skeletal muscle mass. Interfering with Fox0 prevented muscle wasting associated with cancer and sepsis, and even promoted muscle growth. This is likely relevant to any disease, condition or lifestyle that leads to muscle wasting.

If you want big muscles without working out, there's hope. In the March 2012 print issue of the FASEB Journal, scientists from the University of Florida report that a family of protein transcription factors, called "Forkhead (Fox0)" plays a significant role in the regulation of skeletal muscle mass. Specifically, they found that interfering with the activity of these transcription factors prevents muscle wasting associated with cancer and sepsis, and even promotes muscle growth. This discovery is likely to be relevant to any disease, condition or lifestyle that leads to muscle wasting, including voluntary inactivity.

Related Articles


"The loss of muscle mass is a major contributor to disease-related deaths," said Andrew R. Judge, Ph.D., a researcher involved in the work from the Department of Physical Therapy at the University of Florida in Gainesville. "FoxO proteins may provide a target for therapies aimed at reducing muscle wasting and thus improving the quality of life and survival rates for patients with many different diseases."

To make this discovery, Judge and colleagues genetically inhibited the activity of "Forkhead boxO" proteins, or "FoxO," in the skeletal muscle of healthy control mice, septic mice, and mice with cancer. The loss of muscle mass in those with cancer and sepsis was significantly decreased by inhibition of FoxO activity. In healthy control animals inhibiting FoxO activity caused an increase in muscle cell size which occurred as a result of protein synthesis.

"No one can deny that the human body was meant to move, and to move often," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "but the reality is that many of us don't move enough, whether because of disease, injury, or simply a busy schedule. This discovery is another important step towards the treatment of muscle wasting in cancer, severe infection or aging -- or to maintain our muscle mass to help face the slings and arrows of outrageous fortune."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. A. Reed, P. B. Sandesara, S. M. Senf, A. R. Judge. Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy. The FASEB Journal, 2011; 26 (3): 987 DOI: 10.1096/fj.11-189977

Cite This Page:

Federation of American Societies for Experimental Biology. "No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity." ScienceDaily. ScienceDaily, 29 February 2012. <www.sciencedaily.com/releases/2012/02/120229105135.htm>.
Federation of American Societies for Experimental Biology. (2012, February 29). No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2012/02/120229105135.htm
Federation of American Societies for Experimental Biology. "No workout? No worries: Scientists prevent muscle loss in mice, despite disease and inactivity." ScienceDaily. www.sciencedaily.com/releases/2012/02/120229105135.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins