Featured Research

from universities, journals, and other organizations

Powerful new cells cloned: Key to immune system disease could lie inside the cheek

Date:
March 21, 2012
Source:
Cardiff University
Summary:
Scientists have produced powerful new cells which can suppress the body's immune system. The cells are obtained by cloning tissue lining the human cheek, a less invasive process than obtaining adult stem cells from bone marrow. The breakthrough offers long term hope for dealing with immune system disorders.

Powerful new cells created by Cardiff scientists from cheek lining tissue could offer the answer to disorders of the immune system.
Credit: © pressmaster / Fotolia

Powerful new cells created by Cardiff scientists from cheek lining tissue could offer the answer to disorders of the immune system. While the body's immune system protects against many diseases, it can also be harmful. Using white blood cells (lymphocytes), the system can attack insulin-producing cells, causing diabetes, or cause the body to reject transplanted organs.

A team from the School of Dentistry led by Professor Phil Stephens, with colleagues from Stockholm's Karolinska Institute, have found a new group of cells with a powerful ability to suppress the immune system's action.

The team took oral lining cells from the insides of patients' cheeks and cloned them. Laboratory tests showed that even small doses of the cells could completely inhibit the lymphocytes.

The breakthrough suggests that the cheek cells have wide-ranging potential for future therapies for immune system-related diseases. Existing immune system research has focused on adult stem cells, particularly those derived from bone marrow. The cheek tissue cells are much stronger in their action.

Dr Lindsay Davies, a member of the Cardiff team, said: "At this stage, these are only laboratory results. We have yet to recreate the effect outside the laboratory and any treatments will be many years away. However, these cells are extremely powerful and offer promise for combating a number of diseases. They are also easy to collect -- bone marrow stem cells require an invasive biopsy, whereas we just harvest a small biopsy from inside the mouth."

The findings have just been published online in Stem Cells and Development. The team has now been funded by the Medical Research Council to investigate the cloned cells further.


Story Source:

The above story is based on materials provided by Cardiff University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lindsay C. Davies, Helena Lφnnies, Matthew Locke, Berit Sundberg, Kerstin Rosendahl, Cecilia Gφtherstrφm, Katarina Le Blanc, Phil Stephens. Oral Mucosal Progenitor Cells Are Potently Immunosuppressive in a Dose-Independent Manner. Stem Cells and Development, 2012; 120207091647004 DOI: 10.1089/scd.2011.0434

Cite This Page:

Cardiff University. "Powerful new cells cloned: Key to immune system disease could lie inside the cheek." ScienceDaily. ScienceDaily, 21 March 2012. <www.sciencedaily.com/releases/2012/03/120321105340.htm>.
Cardiff University. (2012, March 21). Powerful new cells cloned: Key to immune system disease could lie inside the cheek. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2012/03/120321105340.htm
Cardiff University. "Powerful new cells cloned: Key to immune system disease could lie inside the cheek." ScienceDaily. www.sciencedaily.com/releases/2012/03/120321105340.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) — A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) — Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) — New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins