Featured Research

from universities, journals, and other organizations

Estrogen is responsible for slow wound healing in women, study finds

Date:
April 2, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
Estrogen causes wounds in women to heal slower than in men -- who have lower levels of estrogen -- says a new study. Researchers provide the first evidence that mild injury response in the eye is fundamentally different in males and females because of estrogen.

Estrogen causes wounds in women to heal slower than in men -- who have lower levels of estrogen -- says a new study published in the April 2012 issue of the FASEB Journal. In the report, scientists from the University of California, Berkeley, provide the first evidence that mild injury response in the eye is fundamentally different in males and females because of estrogen.

Related Articles


This discovery provides new clues for successfully treating a wide range of inflammatory diseases such as dry eye disease, rheumatoid arthritis, lupus, multiple sclerosis, and scleroderma.

"We hope that our finding will spur research efforts into delineating sex-specific differences and estrogen regulation of intrinsic circuits that determine the outcome of healthy and routine injury responses," said Karsten Gronert, Ph.D., a researcher involved in the work from the University of California, Berkeley, Vision Science Program, School of Optometry in Berkeley, Calif. "Auto-immune diseases in general are not triggered by a single event; hence, understanding what leads to a recurrent dysregulation of fundamental injury responses may help us treat and/or prevent the development of female-specific diseases."

To make this discovery, Gronert and colleagues administered a mild abrasion injury to the front of the eye of genetically similar male and female mice, and analyzed wound healing by image analysis. To test the role of estrogen, they gave male mice estrogen eye drops and/or drugs that activate specific estrogen receptors. Gene expression of essential enzymes was quantified for the formation of protective lipid signals, specific receptors that mediate their bioactivity, as well as estrogen receptors in mouse corneas and human/mouse epithelial cell cultures. The formation of protective lipid signals was analyzed by a mass-spectrometry based lipidomic method. They found that estrogen negatively affects a highly evolved protective lipid circuit, called "15-lipoxygenase-Lipoxin A4" that has recently emerged as an important protective pathway in many diseases. This pathway balances the activity of pro-inflammatory signals to promote wound healing and to keep inflammation within safe ranges.

"This study goes a long way to explaining gender differences in inflammation and its resolution," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "It's long been known that women suffer more than men from chronic inflammatory diseases such as lupus or rheumatoid arthritis; this study suggests that estrogen itself is responsible for that difference and pinpoints the molecular pathways that estrogen affects. Molecules that promote the resolution of inflammation show promise as new treatments for autoimmune disease."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. B. Wang, K. M. Hu, K. J. Seamon, V. Mani, Y. Chen, K. Gronert. Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea. The FASEB Journal, 2011; 26 (4): 1506 DOI: 10.1096/fj.11-198036

Cite This Page:

Federation of American Societies for Experimental Biology. "Estrogen is responsible for slow wound healing in women, study finds." ScienceDaily. ScienceDaily, 2 April 2012. <www.sciencedaily.com/releases/2012/04/120402094341.htm>.
Federation of American Societies for Experimental Biology. (2012, April 2). Estrogen is responsible for slow wound healing in women, study finds. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2012/04/120402094341.htm
Federation of American Societies for Experimental Biology. "Estrogen is responsible for slow wound healing in women, study finds." ScienceDaily. www.sciencedaily.com/releases/2012/04/120402094341.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins