Featured Research

from universities, journals, and other organizations

Study resolves debate on human cell shut-down process

Date:
April 12, 2012
Source:
University of Liverpool
Summary:
Researchers have resolved the debate over the mechanisms involved in the shut-down process during cell division in the body.

University of Liverpool researchers have resolved the debate over the mechanisms involved in the shut-down process during cell division in the body.

Research findings, published in the journal PNAS, may contribute to future studies on how scientists could manipulate this shut-down process to ensure that viruses and other pathogens do not enter the cells of the body and cause harm.

Previous research has shown that when cells divide, they cannot perform any other task apart from this one. They cannot, for example, take in food and fluids at the same time as managing the important process of dividing into 'daughter cells' to replicate the body's genetic information. Cells, instead, shut-down the intake of food and fluid during cell division and for many years it was thought that they did this by preventing a vehicle -- called a receptor -- from transporting nutrients through the cell membrane.

In recent years scientists have shown evidence to suggest that this theory may be wrong. Scientists have argued that the cell does not shut down the mechanisms that allow food and fluid to enter the cell as previously thought, but rather the receptors that transport this fuel are absent altogether during cell division, allowing the cell to focus on the one task of dividing.

Studies at Liverpool, however, have now shown that the original theory, first documented in 1965, is accurate. The receptors are present and able to transport food and fluid during cell division, but the mechanism that allows them through the membrane of the cell shuts-down until cell division is complete.

Dr Stephen Royle, from the University's Institute of Translational Medicine, explains: "We know that cells in the body do not have the ability to multi-task during cell division. It can only focus on the job of dividing and not on other important tasks such as uptake of nutrients. If we think of the cell membrane like a dock at a port and the receptors as a boat delivering cargo, we have shown that the boat, or receptor, is present but the dock, or membrane, does not allow it to unload or go any further.

"Viruses and pathogens use the same route into cells as nutrients, so the next stage of this work is to identify the trigger for this shut-down process, so that we understand whether this on/off switch can be manipulated to prevent harmful infections passing through the cell membrane. This is a long way in the future, but this work puts us closer to understanding how the cells in the body work."

The work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC).


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. B. Fielding, A. K. Willox, E. Okeke, S. J. Royle. Clathrin-mediated endocytosis is inhibited during mitosis. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1117401109

Cite This Page:

University of Liverpool. "Study resolves debate on human cell shut-down process." ScienceDaily. ScienceDaily, 12 April 2012. <www.sciencedaily.com/releases/2012/04/120412105706.htm>.
University of Liverpool. (2012, April 12). Study resolves debate on human cell shut-down process. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2012/04/120412105706.htm
University of Liverpool. "Study resolves debate on human cell shut-down process." ScienceDaily. www.sciencedaily.com/releases/2012/04/120412105706.htm (accessed April 19, 2014).

Share This



More Plants & Animals News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Vermont Goat Meat Gives Refugees Taste of Home

Vermont Goat Meat Gives Refugees Taste of Home

AP (Apr. 18, 2014) Dairy farmers and ethnic groups in Vermont are both benefiting from a unique collaborative effort that's feeding a growing need for fresh and affordable goat meat. (April 18) Video provided by AP
Powered by NewsLook.com
First Ever 'Female Penis' Discovered In Animal Kingdom

First Ever 'Female Penis' Discovered In Animal Kingdom

Newsy (Apr. 18, 2014) Not only are these newly discovered bugs' sex organs reversed, but they also mate for up to 70 hours. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
The Great British Farmland Boom

The Great British Farmland Boom

Reuters - Business Video Online (Apr. 17, 2014) Britain's troubled Co-operative Group is preparing to cash in on nearly 18,000 acres of farmland in one of the biggest UK land sales in decades. As Ivor Bennett reports, the market timing couldn't be better, with farmland prices soaring over 270 percent in the last 10 years. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins