Featured Research

from universities, journals, and other organizations

New yeast prion helps cells survive

Date:
April 23, 2012
Source:
RIKEN
Summary:
One of the greatest mysterious in cellular biology has been given a new twist. Researchers now show that prions, proteins that transmit heritable information without DNA or RNA, can contribute to drug resistance and cellular adaptation. Their discovery of a yeast prion with these properties demonstrates the active role of the prion conversion in cellular fitness adaptation, providing new insights into the potentially broader function of prions in living organisms.

[MOD+] yeast contain Mod5 aggregates (upper) and acquire resistance to an antifungal agent, fluconazole (lower).
Credit: Image courtesy of RIKEN

One of the greatest mysterious in cellular biology has been given a new twist thanks to findings reported in Science. Researchers at the RIKEN Brain Science Institute show that prions, proteins that transmit heritable information without DNA or RNA, can contribute to drug resistance and cellular adaptation. Their discovery of a yeast prion with these properties demonstrates the active role of the prion conversion in cellular fitness adaptation, providing new insights into the potentially broader function of prions in living organisms.

Related Articles


Since their discovery in the 1960s, the class of misfolded proteins known as prions has posed a fundamental challenge to the foundation of molecular biology: the idea that heritable information flows from DNA and RNA to protein, but never from protein to any other molecule. Contrary to this rule, prions are able to transmit information from one molecule to another through the transmission of their misfolded shape, with devastating consequences in diseases such as mad cow disease and Creutzfeldt-Jakob disease. The broader implications of this unusual transmission mechanism, however, are not well understood.

Among these implications, research on yeast prions has suggested that beyond their well-known role in diseases, some prions may confer survival advantages by helping organisms respond to environmental stress. To explore this idea, the BSI research team screened a wide range of different genes in budding yeast for previously-undiscovered prions. Out of 6000 genes screened, they found a new yeast prion protein "Mod5" with the unusual property that it lacks the glutamine and asparagine-rich amino acid sequences characteristic of other yeast prions. Sequences like these are thought to contribute to forming amyloid aggregates, the mechanism by which prions propagate.

Despite lacking these sequences, Mod5 forms amyloid aggregates just like other yeast prions. Unlike the destructive role such aggregates play in well-known prion diseases, however, the researchers showed that Mod5 aggregates actually help the yeast, by granting it cellular resistance to antifungal agents. This advantage is so important that the yeast actually increases prion conversion when the pressure is on, as the researchers found when they applied antifungal drugs to the yeast.

These results demonstrate that the Mod5 yeast prion contributes to cell survival under environmental stress, through selection playing a key role in evolutionary adaptation. This insight marks a breakthrough in our understanding of the evolutionary role of prions and their unique form of inheritance, promising new avenues in the battle to contain and treat some of the world's most dangerous infectious diseases.


Story Source:

The above story is based on materials provided by RIKEN. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. Suzuki, N. Shimazu, M. Tanaka. A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress. Science, 2012; 336 (6079): 355 DOI: 10.1126/science.1219491

Cite This Page:

RIKEN. "New yeast prion helps cells survive." ScienceDaily. ScienceDaily, 23 April 2012. <www.sciencedaily.com/releases/2012/04/120423105000.htm>.
RIKEN. (2012, April 23). New yeast prion helps cells survive. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2012/04/120423105000.htm
RIKEN. "New yeast prion helps cells survive." ScienceDaily. www.sciencedaily.com/releases/2012/04/120423105000.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Praying Mantis Looks Long Before It Leaps

Praying Mantis Looks Long Before It Leaps

Reuters - Innovations Video Online (Mar. 5, 2015) Slowed-down footage of the leaps of praying mantises show the insect&apos;s extraordinary precision, say researchers. Video provided by Reuters
Powered by NewsLook.com
Octopus Grabs Camera and Turns It Around On Photographer

Octopus Grabs Camera and Turns It Around On Photographer

Buzz60 (Mar. 5, 2015) A photographer got the shot of a lifetime, or rather an octopus did, when it grabbed the camera and turned it around to take an amazing picture of the photographer. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com
Ringling Bros. Eliminating Elephant Acts

Ringling Bros. Eliminating Elephant Acts

AP (Mar. 5, 2015) The Ringling Bros. and Barnum & Bailey Circus is ending its iconic elephant acts. The circus&apos; parent company, Feld Entertainment, told the AP exclusively that the acts will be phased out by 2018 over growing public concern about the animals. (March 5) Video provided by AP
Powered by NewsLook.com
Raw: Tourists Visit Rare Grey Whales in Mexico

Raw: Tourists Visit Rare Grey Whales in Mexico

AP (Mar. 4, 2015) Once nearly extinct, grey whales now migrate in their thousands to Mexico&apos;s Vizcaino reserve in Baja California, in search of warmer waters to mate and give birth. Tourists flock to the reserve to see the whales, measuring up to 49 feet long. (March 4) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins