Featured Research

from universities, journals, and other organizations

Both innate and adaptive immune responses are critical to the control of influenza

Date:
June 29, 2012
Source:
Public Library of Science
Summary:
Both innate and adaptive immune responses play an important role in controlling influenza virus infection, according to a new study.

Both innate and adaptive immune responses play an important role in controlling influenza virus infection, according to a study, published in the Open Access journal PLoS Computational Biology, by researchers from Oakland University, Michigan, and Los Alamos National Laboratory, New Mexico, USA.

Influenza, as a contagious respiratory illness remains a major public health problem worldwide. Seasonal and pandemic influenza results in approximately 3 to 569 million cases of severe illness and approximately 250,000 to 500,000 deaths worldwide. Although most infected subjects with intact immune systems are able to clear the virus without developing serious flu complications, the biological factors responsible for viral control remain unclear.

To investigate the factors for viral control, the researchers developed mathematical models that included both innate and adaptive immune responses to the virus. These models were used to study the viral dynamics of the influenza virus infection in horses. After infection, viral levels rise rapidly, reach a peak and fall, then they attain a low plateau that can be followed in some animals by a second peak. Ultimately, viral levels decline and the infection is cleared. By comparing modeling predictions with experimental data, researchers examined the relative roles of availability of cells susceptible to infection, so-called target cells, and innate and adaptive immune responses in controlling the virus.

The research showed that the two-part innate immune response, generated by natural killer cells, and the antiviral effect caused by interferon, a naturally produced protective molecule, can explain the first rapid viral decline and subsequent second viral peak. The second peak comes about because as the viral level falls, the immune response also falls allowing the virus the opportunity to grow back before the adaptive ultimately clears it.

However, for eventual viral clearance it is the body's adaptive immune response that is needed.

The data analyzed were from equine influenza virus infection in horses. However, similar viral kinetic profiles have been observed in humans infected with the influenza virus. The authors conclude that the study can be used to explain the viral and interferon kinetics observed during a typical influenza virus infection.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kasia A. Pawelek, Giao T. Huynh, Michelle Quinlivan, Ann Cullinane, Libin Rong, Alan S. Perelson. Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses. PLoS Computational Biology, 2012; 8 (6): e1002588 DOI: 10.1371/journal.pcbi.1002588

Cite This Page:

Public Library of Science. "Both innate and adaptive immune responses are critical to the control of influenza." ScienceDaily. ScienceDaily, 29 June 2012. <www.sciencedaily.com/releases/2012/06/120629005452.htm>.
Public Library of Science. (2012, June 29). Both innate and adaptive immune responses are critical to the control of influenza. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2012/06/120629005452.htm
Public Library of Science. "Both innate and adaptive immune responses are critical to the control of influenza." ScienceDaily. www.sciencedaily.com/releases/2012/06/120629005452.htm (accessed August 1, 2014).

Share This




More Plants & Animals News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Visitors Feel Part of the Pack at Wolf Preserve

Visitors Feel Part of the Pack at Wolf Preserve

AP (July 31, 2014) Seacrest Wolf Preserve on the northern Florida panhandle allows more than 10,000 visitors each year to get up close and personal with Arctic and British Columbian Wolves. (July 31) Video provided by AP
Powered by NewsLook.com
Florida Panther Rebound Upsets Ranchers

Florida Panther Rebound Upsets Ranchers

AP (July 31, 2014) With Florida's panther population rebounding, some ranchers complain the protected predators are once again killing their calves. (July 31) Video provided by AP
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Raw: Thousands Flocking to German Crop Circle

Raw: Thousands Flocking to German Crop Circle

AP (July 30, 2014) Thousands of people are trekking to a Bavarian farmer's field to check out a mysterious set of crop circles. (July 30) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins