Featured Research

from universities, journals, and other organizations

Mutation rates in cancer cells strongly linked to how chromatin is organized

Date:
July 26, 2012
Source:
Centre for Genomic Regulation
Summary:
Inside our cells, DNA is packed in a dense structure called chromatin so the cell can replicate, repair any DNA damage during cell division, and control which genes are expressed. Researchers have found that chromatin has a lot to do with where mutations occur in the genome in cancer cells.

Inside our cells, DNA is packed in a dense structure called chromatin so the cell can replicate, repair any DNA damage during cell division, and control which genes are expressed. Researchers from the Center for Genomic Regulation CRG have found that chromatin has a lot to do with where mutations occur in the genome in cancer cells.

Cancer is considered to be a genetic disease, with its leading cause the various mutations occurring while the genome is duplicated during cell division. Many genetic and epigenetic features have been proposed to influence the rate at which mutations occur along the genome. Researchers from the CRG have found that chromatin organization is the feature most strongly linked with mutation rates, at least in cancer cells.

The researchers studied samples from different types of tissues and with different types of mutations in cancer cells like leukemia, melanoma, small lung cancer and prostate cancer. They obtained the data through open access repositories of genome databases. Since the first genome was sequenced, all genomic data from public funded research are supposed to freely available through these repositories. Among many other interests, one strong point of using data already collected by multiple other scientists is that biases are cancelled out because of the amount of experiments.

The principal investigator, ICREA research professor Ben Lehner, says 'Large-scale experiments such as the cancer genome projects mean that in biology it is now often possible to test an idea using data that has already been generated. The data from these projects can be used by groups worldwide to help us learn about the causes of cancer, but they can also be used to understand some basic problems in genetics such as why some regions of the genome mutate faster than others.'

The study was funded by the European Research Council (ERC), the EU Framework 7 project 4DCellFate, the Ministry of Science and Technology of Spain and Agaur.


Story Source:

The above story is based on materials provided by Centre for Genomic Regulation. Note: Materials may be edited for content and length.


Cite This Page:

Centre for Genomic Regulation. "Mutation rates in cancer cells strongly linked to how chromatin is organized." ScienceDaily. ScienceDaily, 26 July 2012. <www.sciencedaily.com/releases/2012/07/120726122034.htm>.
Centre for Genomic Regulation. (2012, July 26). Mutation rates in cancer cells strongly linked to how chromatin is organized. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2012/07/120726122034.htm
Centre for Genomic Regulation. "Mutation rates in cancer cells strongly linked to how chromatin is organized." ScienceDaily. www.sciencedaily.com/releases/2012/07/120726122034.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins