Featured Research

from universities, journals, and other organizations

Mutation rates in cancer cells strongly linked to how chromatin is organized

Date:
July 26, 2012
Source:
Centre for Genomic Regulation
Summary:
Inside our cells, DNA is packed in a dense structure called chromatin so the cell can replicate, repair any DNA damage during cell division, and control which genes are expressed. Researchers have found that chromatin has a lot to do with where mutations occur in the genome in cancer cells.

Inside our cells, DNA is packed in a dense structure called chromatin so the cell can replicate, repair any DNA damage during cell division, and control which genes are expressed. Researchers from the Center for Genomic Regulation CRG have found that chromatin has a lot to do with where mutations occur in the genome in cancer cells.

Related Articles


Cancer is considered to be a genetic disease, with its leading cause the various mutations occurring while the genome is duplicated during cell division. Many genetic and epigenetic features have been proposed to influence the rate at which mutations occur along the genome. Researchers from the CRG have found that chromatin organization is the feature most strongly linked with mutation rates, at least in cancer cells.

The researchers studied samples from different types of tissues and with different types of mutations in cancer cells like leukemia, melanoma, small lung cancer and prostate cancer. They obtained the data through open access repositories of genome databases. Since the first genome was sequenced, all genomic data from public funded research are supposed to freely available through these repositories. Among many other interests, one strong point of using data already collected by multiple other scientists is that biases are cancelled out because of the amount of experiments.

The principal investigator, ICREA research professor Ben Lehner, says 'Large-scale experiments such as the cancer genome projects mean that in biology it is now often possible to test an idea using data that has already been generated. The data from these projects can be used by groups worldwide to help us learn about the causes of cancer, but they can also be used to understand some basic problems in genetics such as why some regions of the genome mutate faster than others.'

The study was funded by the European Research Council (ERC), the EU Framework 7 project 4DCellFate, the Ministry of Science and Technology of Spain and Agaur.


Story Source:

The above story is based on materials provided by Centre for Genomic Regulation. Note: Materials may be edited for content and length.


Cite This Page:

Centre for Genomic Regulation. "Mutation rates in cancer cells strongly linked to how chromatin is organized." ScienceDaily. ScienceDaily, 26 July 2012. <www.sciencedaily.com/releases/2012/07/120726122034.htm>.
Centre for Genomic Regulation. (2012, July 26). Mutation rates in cancer cells strongly linked to how chromatin is organized. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2012/07/120726122034.htm
Centre for Genomic Regulation. "Mutation rates in cancer cells strongly linked to how chromatin is organized." ScienceDaily. www.sciencedaily.com/releases/2012/07/120726122034.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins