Featured Research

from universities, journals, and other organizations

Writing the book in DNA: Geneticist encodes his book in life's language

Date:
August 17, 2012
Source:
Harvard Medical School
Summary:
Using next-generation sequencing technology and a novel strategy to encode 1,000 times the largest data size previously achieved in DNA, a geneticist encodes his book in life's language.

Using next-generation sequencing technology and a novel strategy to encode 1,000 times the largest data size previously achieved in DNA, a Harvard geneticist encodes his book in life's language.
Credit: Image courtesy of Harvard Medical School

Using next-generation sequencing technology and a novel strategy to encode 1,000 times the largest data size previously achieved in DNA, a Harvard geneticist encodes his book in life's language.

Although George Church's next book doesn't hit the shelves until Oct. 2, it has already passed an enviable benchmark: 70 billion copies -- roughly triple the sum of the top 100 books of all time.

And they fit on your thumbnail.

That's because Church, the Robert Winthrop Professor of Genetics at Harvard Medical School and a founding core faculty member of the Wyss Institute for Biomedical Engineering at Harvard University, and his team encoded the book, Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves, in DNA, which they then read and copied.

Biology's databank, DNA has long tantalized researchers with its potential as a storage medium: fantastically dense, stable, energy efficient and proven to work over a timespan of some 3.5 billion years. While not the first project to demonstrate the potential of DNA storage, Church's team married next-generation sequencing technology with a novel strategy to encode 1,000 times the largest amount of data previously stored in DNA.

The team reports its results in the Aug. 17 issue of the journal Science.

The researchers used binary code to preserve the text, images and formatting of the book. While the scale is roughly what a 5 -inch floppy disk once held, the density of the bits is nearly off the charts: 5.5 petabits, or 1 million gigabits, per cubic millimeter. "The information density and scale compare favorably with other experimental storage methods from biology and physics," said Sri Kosuri, a senior scientist at the Wyss Institute and senior author on the paper. The team also included Yuan Gao, a former Wyss postdoc who is now an associate professor of biomedical engineering at Johns Hopkins University.

And where some experimental media -- like quantum holography -- require incredibly cold temperatures and tremendous energy, DNA is stable at room temperature. "You can drop it wherever you want, in the desert or your backyard, and it will be there 400,000 years later," Church said.

Reading and writing in DNA is slower than in other media, however, which makes it better suited for archival storage of massive amounts of data, rather than for quick retrieval or data processing. "Imagine that you had really cheap video recorders everywhere," Church said. "Just paint walls with video recorders. And for the most part they just record and no one ever goes to them. But if something really good or really bad happens you want to go and scrape the wall and see what you got. So something that's molecular is so much more energy efficient and compact that you can consider applications that were impossible before."

About four grams of DNA theoretically could store the digital data humankind creates in one year.

Although other projects have encoded data in the DNA of living bacteria, the Church team used commercial DNA microchips to create standalone DNA. "We purposefully avoided living cells," Church said. "In an organism, your message is a tiny fraction of the whole cell, so there's a lot of wasted space. But more importantly, almost as soon as a DNA goes into a cell, if that DNA doesn't earn its keep, if it isn't evolutionarily advantageous, the cell will start mutating it, and eventually the cell will completely delete it."

In another departure, the team rejected so-called "shotgun sequencing," which reassembles long DNA sequences by identifying overlaps in short strands. Instead, they took their cue from information technology, and encoded the book in 96-bit data blocks, each with a 19-bit address to guide reassembly. Including jpeg images and HTML formatting, the code for the book required 54,898 of these data blocks, each a unique DNA sequence. "We wanted to illustrate how the modern world is really full of zeroes and ones, not As through Zs alone," Kosuri said.

The team discussed including a DNA copy with each print edition of Regenesis. But in the book, Church and his co-author, the science writer Ed Regis, argue for careful supervision of synthetic biology and the policing of its products and tools. Practicing what they preach, the authors decided against a DNA insert -- at least until there has been far more discussion of the safety, security and ethics of using DNA this way. "Maybe the next book," Church said.

This work was supported by the U.S. Office of Naval Research (N000141010144), Agilent Technologies and the Wyss Institute.


Story Source:

The above story is based on materials provided by Harvard Medical School. The original article was written by R. Alan Leo. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. M. Church, Y. Gao, S. Kosuri. Next-Generation Digital Information Storage in DNA. Science, 2012; DOI: 10.1126/science.1226355

Cite This Page:

Harvard Medical School. "Writing the book in DNA: Geneticist encodes his book in life's language." ScienceDaily. ScienceDaily, 17 August 2012. <www.sciencedaily.com/releases/2012/08/120817135601.htm>.
Harvard Medical School. (2012, August 17). Writing the book in DNA: Geneticist encodes his book in life's language. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2012/08/120817135601.htm
Harvard Medical School. "Writing the book in DNA: Geneticist encodes his book in life's language." ScienceDaily. www.sciencedaily.com/releases/2012/08/120817135601.htm (accessed April 23, 2014).

Share This



More Plants & Animals News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Leopard Bites Man in India

Raw: Leopard Bites Man in India

AP (Apr. 22, 2014) A leopard caused panic in the city of Chandrapur on Monday when it sprung from the roof of a house and charged at rescue workers. (April 22) Video provided by AP
Powered by NewsLook.com
Iowa College Finds Beauty in Bulldogs

Iowa College Finds Beauty in Bulldogs

AP (Apr. 22, 2014) Drake University hosts 35th annual Beautiful Bulldog Contest. (April 21) Video provided by AP
Powered by NewsLook.com
805-Pound Shark Caught Off The Coast Of Florida

805-Pound Shark Caught Off The Coast Of Florida

Newsy (Apr. 22, 2014) One Florida fisherman caught a 805-pound shark off the coast of Florida earlier this month. Video provided by Newsy
Powered by NewsLook.com
Breakfast Foods Are Getting Pricier

Breakfast Foods Are Getting Pricier

AP (Apr. 21, 2014) Breakfast is now being served with a side of sticker shock. The cost of morning staples like bacon, coffee and orange juice is on the rise because of global supply problems. (April 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins