Featured Research

from universities, journals, and other organizations

Anthrax targets

Date:
August 20, 2012
Source:
Inderscience Publishers
Summary:
A trawl of the genome of the deadly bacterium Bacillus anthracis has revealed a clutch of targets for new drugs to combat an epidemic of anthrax or a biological weapons attack. The targets are all proteins that are found in the bacteria but not in humans and are involved in diverse bacterial processes such as metabolism, cell wall synthesis and bacterial persistence. The discovery of a range of targets might bode well for creating a drug cocktail that could preclude the emergence of drug resistance.

A trawl of the genome of the deadly bacterium Bacillus anthracis has revealed a clutch of targets for new drugs to combat an epidemic of anthrax or a biological weapons attack. The targets are all proteins that are found in the bacteria but not in humans and are involved in diverse bacterial processes such as metabolism, cell wall synthesis and bacterial persistence. The discovery of a range of targets might bode well for creating a drug cocktail that could preclude the emergence of drug resistance.

Related Articles


Ravi Gutlapalli of the Department of Biotechnology, at Acharya Nagarjuna University in Guntur, Andhra Pradesh, India, and colleagues there and at Osmanaia University College for Women in Hyderabad, suggest that the search for drugs to fight Bacillus anthracis is of increasing importance as we face an ongoing threat of its use as a biological weapon. The team has now carried out a search of the bacterial genome and identified 270 non-redundant, non-human homologous genes and 103 essential genes of the bacteria as possible drug targets.

The team explains that they have fished out sixteen membrane-bound proteins, seven proteases and three adhesion molecules that are all novel from their trawl any one of which might now be used in the rational design of new drugs with previously unused modes of action. This latter point is most important in reducing the chances of the bacteria quickly evolving resistance.

Early diagnosis and treatment with potent antibiotics is essential in any of the three clinical forms of anthrax: cutaneous, gastrointestinal and pulmonary. Unfortunately, the bacteria have evolved resistance to common antibiotics including ciprofloxacin, doxycycline and beta-lactam type drugs. The team now hopes that its identification of a range of novel targets for antibiotics will allow medicinal chemists to quickly screen for activity among diverse molecules as putative antibiotics.

With several possible targets in hand, researchers now need to create homology models of each against which potential drugs might be screened on the computer and thence synthesize in the laboratory and tested against the bacteria under secure conditions.


Story Source:

The above story is based on materials provided by Inderscience Publishers. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ravi V. Gutlapalli, Jyothsna L. Ambaru, Pavani Darla, K.R.S. Sambasiva Rao. Genome wide search for identification of potential drug targets in Bacillus anthracis. International Journal of Computational Biology and Drug Design, 2012; 5 (2): 164 DOI: 10.1504/IJCBDD.2012.048311

Cite This Page:

Inderscience Publishers. "Anthrax targets." ScienceDaily. ScienceDaily, 20 August 2012. <www.sciencedaily.com/releases/2012/08/120820132337.htm>.
Inderscience Publishers. (2012, August 20). Anthrax targets. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2012/08/120820132337.htm
Inderscience Publishers. "Anthrax targets." ScienceDaily. www.sciencedaily.com/releases/2012/08/120820132337.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins