Featured Research

from universities, journals, and other organizations

Anchoring proteins influence glucose metabolism and insulin release

Date:
September 4, 2012
Source:
EMBO - excellence in life sciences
Summary:
Scientists have discovered a new control point that could be important as a drug target for the treatment of diabetes and other metabolic diseases. A-kinase anchoring proteins or AKAPs are known to influence the spatial distribution of kinases within the cell, crucial enzymes that control important molecular events related to the regulation of glucose levels in the blood.

Scientists from the United States and Sweden have discovered a new control point that could be important as a drug target for the treatment of diabetes and other metabolic diseases. A-kinase anchoring proteins or AKAPs are known to influence the spatial distribution of kinases within the cell, crucial enzymes that control important molecular events related to the regulation of glucose levels in the blood.

Related Articles


In a new study published in The EMBO Journal, the team of researchers led by Simon Hinke and John Scott reveal for the first time that AKAPs influence the levels of glucose in the body by coordinating the spatial positioning of phosphatases, naturally occurring enzymes that counteract the effects of kinase enzymes.

"Our discovery that anchored enzymes contribute to the regulation of cellular events that underlie diabetes may help us to move more rapidly toward new therapies to control this increasingly prevalent metabolic disease," commented John Scott, Edwin G. Krebs-Hilma Speights Professor of Pharmacology at the University of Washington School of Medicine, Seattle and an investigator of the Howard Hughes Medical Institute. "The observation that AKAP 150 functions by coordinating phosphatase activity in the cell reveals a new role for these anchoring proteins in the control of glucose metabolism and related metabolic disorders. It also suggests that new drugs that interfere with the role of anchoring proteins are possible therapeutic interventions to treat chronic diseases such as diabetes."

The researchers used imaging techniques as well as genetic modification of isolated insulin-secreting cells and whole mice to investigate the impact of anchoring proteins on glucose metabolism and insulin release. Mice that lacked the gene for the AKAP150 anchoring protein produced less insulin from beta cells in the islets of Langerhans. However, they coped better with limited amounts of hormone due to increased sensitivity to insulin in the target tissues (skeletal muscle). The scientists showed that these effects are due to a seven-amino-acid sequence in the anchor protein that directly interacts with the surface of the phosphatase enzyme.

The release of insulin is the main way in which the levels of glucose are controlled in the body. If it is possible to develop drugs that target the region where anchoring proteins specifically interact with phosphatase enzymes it is feasible that insulin sensitivity could be improved in selected tissues such as skeletal muscle. This would represent a valuable new molecular control point that might offer clinical benefits for diabetics, individuals with other metabolic disorders and patients who are being treated with immunosuppressive drugs following organ transplantation.


Story Source:

The above story is based on materials provided by EMBO - excellence in life sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Simon A Hinke, Manuel F Navedo, Allison Ulman, Jennifer L Whiting, Patrick J Nygren, Geng Tian, Antonio J Jimenez-Caliani, Lorene K Langeberg, Vincenzo Cirulli, Anders Tengholm, Mark L Dell’Acqua, L Fernando Santana, John D Scott. Anchored phosphatases modulate glucose homeostasis. The EMBO Journal, 2012; DOI: 10.1038/emboj.2012.244

Cite This Page:

EMBO - excellence in life sciences. "Anchoring proteins influence glucose metabolism and insulin release." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120904100035.htm>.
EMBO - excellence in life sciences. (2012, September 4). Anchoring proteins influence glucose metabolism and insulin release. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2012/09/120904100035.htm
EMBO - excellence in life sciences. "Anchoring proteins influence glucose metabolism and insulin release." ScienceDaily. www.sciencedaily.com/releases/2012/09/120904100035.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.S. Ebola Response Measures Demonstrated

U.S. Ebola Response Measures Demonstrated

AP (Oct. 31, 2014) Officials in the Washington area showed off Ebola response measures being taken at Dulles International Airport and the National Institutes of Health. (Oct. 31) Video provided by AP
Powered by NewsLook.com
Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins