Featured Research

from universities, journals, and other organizations

Camels to help fight Alzheimer's? New class of antibody from camelids that can cross the blood-brain barrier

Date:
October 1, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
Could camels help fight Alzheimer's disease? Scientists have announced a discovery that may lead to enhanced imaging of, and improved drug delivery to the brain. New research describes a new class of antibody from camelids that can cross the blood-brain barrier, diffuse into brain tissue, and reach specific targets. These antibodies may be instrumental for people with brain diseases poorly diagnosed and treated using today's tools.

Could camels help fight Alzheimer's disease? Scientists have announced a discovery that may lead to enhanced imaging of, and improved drug delivery to the brain. A research report appearing in The FASEB Journal, describes an entirely new class of antibody discovered in camelids (camels, dromedaries, llamas, and alpacas) that is able to cross the blood-brain barrier, diffuse into brain tissue, and reach specific targets. Having such antibodies, which are naturally available, may be part of a "game changer" in the outcomes for people with brain diseases that are poorly diagnosed and treated, at best, using today's tools.

"This basic biological investigation opens new pathways toward innovative therapeutic solutions for intractable diseases such as Alzheimer's disease or brain tumors," said Pierre Lafaye, Ph.D., a researcher involved in the work from the Institut Pasteur, PF: Production de Protιines Recombinantes et d'Anticorps -Proteopole in Paris, France. "The importance of this study is the hope that this novel approach may be a useful tool in crossing the blood brain barrier for diagnostic and therapeutic purposes," added Babbette Weksler, MD, Professor of Medicine, Weill Cornell Medical College, New York, NY, another author of the study and editorial board member of The FASEB Journal.

Lafaye and colleagues studied alpacas, a member of the camelid family, and discovered an antibody naturally able to cross the blood brain barrier without chemical modification. Then, additional research showed that after these antibodies entered the brain successfully, they diffused into the brain tissue to reach a target, which in this study was astrocytes. This study shows, for the first time, an antibody penetrated into the brain in vivo, under normal physiological conditions. In addition to the obvious clinical applications of this finding, it opens the doors to new research involving the body's systems for recognizing self v. "nonself."

"Camels may be most famous for helping people travel to the outermost reaches of the desert, but soon they could be also known for helping us reach the innermost parts of our brains," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "It appears that these prized animals are far more capable of helping get to hard-to-reach places than we ever could have imagined."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Li, J.-P. Bourgeois, S. Celli, F. Glacial, A.-M. Le Sourd, S. Mecheri, B. Weksler, I. Romero, P.-O. Couraud, F. Rougeon, P. Lafaye. Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging. The FASEB Journal, 2012; 26 (10): 3969 DOI: 10.1096/fj.11-201384

Cite This Page:

Federation of American Societies for Experimental Biology. "Camels to help fight Alzheimer's? New class of antibody from camelids that can cross the blood-brain barrier." ScienceDaily. ScienceDaily, 1 October 2012. <www.sciencedaily.com/releases/2012/10/121001125243.htm>.
Federation of American Societies for Experimental Biology. (2012, October 1). Camels to help fight Alzheimer's? New class of antibody from camelids that can cross the blood-brain barrier. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2012/10/121001125243.htm
Federation of American Societies for Experimental Biology. "Camels to help fight Alzheimer's? New class of antibody from camelids that can cross the blood-brain barrier." ScienceDaily. www.sciencedaily.com/releases/2012/10/121001125243.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) — The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) — A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) — Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins