Featured Research

from universities, journals, and other organizations

Antibiotic shows promise in treating extensively drug-resistant tuberculosis

Date:
October 18, 2012
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
When tested in patients hospitalized with extensively drug-resistant tuberculosis (XDR-TB) unresponsive to previous treatment, linezolid, an antibiotic used to treat severe bacterial infections, proved largely effective when added to the patients' ongoing TB treatment regimen.

When tested in patients hospitalized with extensively drug-resistant tuberculosis (XDR-TB) unresponsive to previous treatment, linezolid, an antibiotic used to treat severe bacterial infections, proved largely effective when added to the patients' ongoing TB treatment regimen. Also, few patients developed resistance to the drug. These promising findings were tempered, however, by the fact that 82 percent of the patients who received linezolid experienced significant adverse events that may have been related to the drug.

Related Articles


Findings from the study appear in the Oct. 18 issue of the New England Journal of Medicine.

XDR-TB is a form of tuberculosis that is resistant to at least four of the drugs most often used to treat TB. Although XDR-TB is rare, 77 countries worldwide reported at least one case by the end of 2011, according to the World Health Organization. In the United States, at least 57 cases of XDR-TB were reported between 1993 and 2010. Patients infected with XDR-TB typically have very poor clinical outcomes, and with no effective drugs available for their treatment, they often die.

Led by Clifton E. Barry, III, Ph.D., of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, and Sang-Nae Cho, D.V.M., Ph.D., professor of infectious diseases at Yonsei University, South Korea, researchers enrolled at two South Korean hospitals patients with chronic XDR-TB who had failed to respond to any treatment during the six months before enrolling into the study. The patients, predominantly men (72 percent) ranging in age from 20 to 64, were randomly assigned either to immediately begin 600 milligrams (mg) of linezolid once daily as part of their existing treatment regimen (19 patients) or to start the drug after a two-month delay (20 patients). After no longer testing positive for the bacterium or after four months of therapy, whichever came first, participants were then randomly assigned for the next 18 months to continue taking either a daily 600-mg dose of linezolid or a daily 300-mg dose. The patients were regularly monitored for any adverse effects.

After four months, 15 of the 19 patients (79 percent) in the immediate-start group, and 7 of the 20 (35 percent) patients in the delayed-start group no longer tested positive for TB. After six months of treatment with the drug, 87 percent (34 of 39 patients) no longer tested positive for the bacterium.

Adverse effects associated with long-term linezolid use included bone marrow suppression and peripheral and optic neuropathy. In the study, 31 patients (82 percent) experienced clinically significant adverse events that were likely related to the use of drug, but most of these events resolved quickly after briefly stopping the drug or using the lower 300-mg dose, the authors note. Only 3 of those 31 patients permanently discontinued use of the drug because of side effects. Additionally, only 4 of the 38 patients (11 percent) who used the drug for six months or more acquired resistance to linezolid. Thirteen patients completed treatment and have not had a relapse in the 12 months after treatment ended. All of the patients continue to be watched for long-term outcomes.

The authors conclude that linezolid may become an important therapeutic option for XDR-TB cases in the future. It also may form part of a regimen to treat MDR-TB in periods shorter than the two years of therapy standard for such patients now. Yet in both instances, additional clinical trials are needed to identify a dosage that is sufficiently potent yet does not cause significant adverse events.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. Myungsun Lee, Jongseok Lee, Matthew W. Carroll, Hongjo Choi, Seonyeong Min, Taeksun Song, Laura E. Via, Lisa C. Goldfeder, Eunhwa Kang, Boyoung Jin, Hyeeun Park, Hyunkyung Kwak, Hyunchul Kim, Han-Seung Jeon, Ina Jeong, Joon Sung Joh, Ray Y. Chen, Kenneth N. Olivier, Pamela A. Shaw, Dean Follmann, Sun Dae Song, Jong-Koo Lee, Dukhyoung Lee, Cheon Tae Kim, Veronique Dartois, Seung-Kyu Park, Sang-Nae Cho, Clifton E. Barry. Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis. New England Journal of Medicine, 2012; 367 (16): 1508 DOI: 10.1056/NEJMoa1201964

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Antibiotic shows promise in treating extensively drug-resistant tuberculosis." ScienceDaily. ScienceDaily, 18 October 2012. <www.sciencedaily.com/releases/2012/10/121018102728.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2012, October 18). Antibiotic shows promise in treating extensively drug-resistant tuberculosis. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2012/10/121018102728.htm
NIH/National Institute of Allergy and Infectious Diseases. "Antibiotic shows promise in treating extensively drug-resistant tuberculosis." ScienceDaily. www.sciencedaily.com/releases/2012/10/121018102728.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins