Featured Research

from universities, journals, and other organizations

The sense of 'antisense' RNA: Non-coding antisense RNA can be used to stimulate protein production

Date:
October 22, 2012
Source:
International School of Advanced Studies (SISSA)
Summary:
While studying Parkinson's disease, an international research group led by scientists in Italy made a discovery which can improve industrial protein synthesis for therapeutic use. They managed to understand the use of RNA when it is not involved in the protein-coding process: the protein synthesis activity of coding genes can be enhanced, for example, by the activity of the non-coding one called "antisense".

Researchers have managed to understand the use of RNA when it is not involved in the protein-coding process: the protein synthesis activity of coding genes can be enhanced, for example, by the activity of the non-coding one called "antisense".
Credit: SISSA

While studying Parkinson's disease, an international research group led by SISSA scientists in Trieste made a discovery which can improve industrial protein synthesis for therapeutic use. They managed to understand the use of RNA when it is not involved in the protein-coding process: the protein synthesis activity of coding genes can be enhanced, for example, by the activity of the non-coding one called "antisense."

To synthetize proteins, the DNA needs RNA molecules serving as short "transcriptions" of the genetic information. The set of all these RNA molecules is called "transcriptome." In the human transcriptome, along with around 25 thousand sequences of coding RNA (i.e. the sequences involved in the synthesis process), the same number of non-coding RNA sequences can be found. Some of these RNAs are called "antisense" because they are specular to sequences of coding RNA called "sense" (the pairing of a sense and an antisense RNA can be seen as a zip). A study published in the journal Nature, coordinated by a group of SISSA researchers in Trieste, has shown that this particular type of antisense RNA has a strengthening function on the coding activity of the proteins of the corresponding genes.

Very little used to be known of "long, non-codifying" RNA and this new research sheds light on some of these molecules. "We focused on one gene, Uchl1, whose mutations are linked to some hereditary types of Parkinson's disease," stated Stefano Gustincich, Professor at SISSA and coordinator of this research project. "We have seen that the non-coding antisense RNA matched to this gene is made up of two fragments, the real antisense fragment matching with the sense RNA that codifies the protein and the SineB2 sequence. The antisense fragment has the function of a "lock" into which the key of the coding RNA specific for that gene is inserted, while the other one has a stimulating function on protein synthesis."

If you change the antisense fragment with the analogous of another gene, the SineB2 sequence maintains its stimulating function on the new gene.

"This is important," explained Gustincich "because it means that the action of sineB2 could be used to stimulate protein production for therapeutic use -- any protein -- in industrial synthesis processes."

A coding RNA is a molecule that copies the information stored in small DNA fragments (genes). This information is then used to make the new protein. There are different types of non-coding RNA, e.g microRNA and small Interference RNA, known for having an inhibiting effect on the transcription of coding RNA.


Story Source:

The above story is based on materials provided by International School of Advanced Studies (SISSA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Claudia Carrieri, Laura Cimatti, Marta Biagioli, Anne Beugnet, Silvia Zucchelli, Stefania Fedele, Elisa Pesce, Isidre Ferrer, Licio Collavin, Claudio Santoro, Alistair R. R. Forrest, Piero Carninci, Stefano Biffo, Elia Stupka, Stefano Gustincich. Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Nature, 2012; DOI: 10.1038/nature11508

Cite This Page:

International School of Advanced Studies (SISSA). "The sense of 'antisense' RNA: Non-coding antisense RNA can be used to stimulate protein production." ScienceDaily. ScienceDaily, 22 October 2012. <www.sciencedaily.com/releases/2012/10/121022122239.htm>.
International School of Advanced Studies (SISSA). (2012, October 22). The sense of 'antisense' RNA: Non-coding antisense RNA can be used to stimulate protein production. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2012/10/121022122239.htm
International School of Advanced Studies (SISSA). "The sense of 'antisense' RNA: Non-coding antisense RNA can be used to stimulate protein production." ScienceDaily. www.sciencedaily.com/releases/2012/10/121022122239.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

More Coverage


Non-Coding Antisense RNA Can Be Used to Stimulate Protein Production

Oct. 16, 2012 While studying Parkinson's disease, an international research group made a discovery which can improve industrial protein synthesis for therapeutic use. They managed to understand a novel ... read more

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins