Featured Research

from universities, journals, and other organizations

Molecular epidemiological conditions relating to tuberculous and non-tuberculous mycobacteria

Date:
November 8, 2012
Source:
Norwegian School of Veterinary Science
Summary:
A research project studying molecular epidemiological conditions relating to diseases caused by tuberculous and non-tuberculous mycobacteria in the Mubende region of Uganda has increased our understanding of how the interplay between humans, animals and the environment affects the development of such diseases. The project focused in particular on social and risk factors which may possibly prevent the success of a disease control programme in the region.

A research project studying molecular epidemiological conditions relating to diseases caused by tuberculous and non-tuberculous mycobacteria in the Mubende region of Uganda has increased our understanding of how the interplay between humans, animals and the environment affects the development of such diseases. The project focused in particular on social and risk factors which may possibly prevent the success of a disease control programme in the region.

The diseases concerned -- for example tuberculosis in humans or cattle and other host-specific tuberculosis -- are caused by pathogenic bacteria of the Mycobacterium tuberculosis complex (MTC). Non-tuberculous mycobacteria (NMT) have not been so frequently documented as pathogenic agents, but they occur widely in the environment. However, more advanced methods of diagnosis and the fact that immunodeficiency disorders such as HIV/AIDS are widespread have led to NTM now being associated with a broad range of diseases. These bacteria also sometimes occur in larger numbers than MTC in tuberculous lesions.

Adrian Muwonge's doctoral research has revealed a wide range of pathogenic and non-pathogenic mycobacteria in the environment of the Mubende region and this gives cause for concern, given the high occurrence of HIV amongst the local population. He has studied the role that non-tuberculous mycobacteria play in the establishment and development of disease, especially since these bacteria are resistant to anti-mycobacterial drugs.

Most of the isolated non-tuberculous mycobacteria come from drinking water and the soil, but animals also play an important role in the spreading of these bacteria in the environment. Humans are exposed to mycobacteria mostly via untreated drinking water from water sources that they share with domestic and/or wild animals.

Pig farming is widespread in Mubende and the pigs are usually kept in a "free-range" system, where they wander around in the surroundings in search of food. In this way, they become infected with mycobacteria from the soil and water while at the same time infecting the environment themselves. The local people eat a great deal of pork and the occurrence of pathogenic mycobacteria such as M. avium and M. bovis in slaughtered pigs is therefore a cause for concern. Mycobacterial infections are easiest to detect in checks carried out on meat, but the quality control procedures at the abattoirs in this region were found to be unsatisfactory.

A study of the occurrence of tuberculosis in humans in the region showed a high prevalence of tuberculosis, especially amongst those infected by HIV and amongst smokers who live in households of more than six persons. Multi-resistant tuberculous bacteria and high travel costs associated with medical treatment pose problems for the efforts being made to control these infections.

The large number of heterogeneous genotypes of M. tuberculosis in Mubende points to a dynamic and complex tuberculosis epidemiology in this area. Typically, tuberculosis patients were found to be infected with more than one strain of M. tuberculosis and this wasparticularly evident amongst female patients living in urban districts. The occurrence of specific variants of M. tuberculosis in certain geographic areas also indicates that the infection dynamics in urban areas differ from those in rural areas.


Story Source:

The above story is based on materials provided by Norwegian School of Veterinary Science. Note: Materials may be edited for content and length.


Cite This Page:

Norwegian School of Veterinary Science. "Molecular epidemiological conditions relating to tuberculous and non-tuberculous mycobacteria." ScienceDaily. ScienceDaily, 8 November 2012. <www.sciencedaily.com/releases/2012/11/121108073923.htm>.
Norwegian School of Veterinary Science. (2012, November 8). Molecular epidemiological conditions relating to tuberculous and non-tuberculous mycobacteria. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2012/11/121108073923.htm
Norwegian School of Veterinary Science. "Molecular epidemiological conditions relating to tuberculous and non-tuberculous mycobacteria." ScienceDaily. www.sciencedaily.com/releases/2012/11/121108073923.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins