Featured Research

from universities, journals, and other organizations

From rats to people: Gaming platform used to compare memory impairments of rodents and humans with epilepsy

Date:
December 3, 2012
Source:
American Epilepsy Society (AES)
Summary:
A behavioral test widely used on rodents to study spatial learning and memory, the Morris water maze (MWM), was recreated using software developed to create custom video game environments. By creating a virtual reality analogue for humans, it was possible to obtain a direct comparison between the results of studies on a rodent model of temporal lobe epilepsy (TLE), whose spatial memory performance was found to be severely impaired, and patients with TLE.

A behavioral test widely used on rodents to study spatial learning and memory, the Morris water maze (MWM), was recreated using software developed to create custom video game environments. By creating a virtual reality analogue for humans, it was possible to obtain a direct comparison between the results of studies on a rodent model of temporal lobe epilepsy (TLE), whose spatial memory performance was found to be severely impaired, and patients with TLE.

Related Articles


The simulation program developed using the "Source Engine" (ValveTM) software was used to create an environment comparable to the submerged water platform of the Morris water maze. The novel research tool and the striking results it produced were presented today at the American Epilepsy Society's 66th annual meeting here at the San Diego Convention Center.

In this study by researchers from the Neurology department at the Geisel School of Medicine at Dartmouth and the Department of Neurosciences and Mental Health, UCL Institute of Child Health in London, UK, eleven healthy volunteers and six patients with epilepsy were presented with laptop computers and a gamepad controller. After a habituation period, the subjects were "dropped" in the water-filled arena and asked to find a submerged platform as quickly as possible. Electrophysiological recordings were made in the patients with epilepsy to assess oscillatory and single-unit activity during the task and their results showed striking parallels between the patients with epilepsy and the previous rodent data.

"The water-maze is a familiar research tool and the virtual reality version holds great promise for translational research" says Ali S. Titiz, a PhD candidate at the Geisel School of Medicine, and the first author of the study.


Story Source:

The above story is based on materials provided by American Epilepsy Society (AES). Note: Materials may be edited for content and length.


Cite This Page:

American Epilepsy Society (AES). "From rats to people: Gaming platform used to compare memory impairments of rodents and humans with epilepsy." ScienceDaily. ScienceDaily, 3 December 2012. <www.sciencedaily.com/releases/2012/12/121203081615.htm>.
American Epilepsy Society (AES). (2012, December 3). From rats to people: Gaming platform used to compare memory impairments of rodents and humans with epilepsy. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2012/12/121203081615.htm
American Epilepsy Society (AES). "From rats to people: Gaming platform used to compare memory impairments of rodents and humans with epilepsy." ScienceDaily. www.sciencedaily.com/releases/2012/12/121203081615.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins