Featured Research

from universities, journals, and other organizations

From rats to people: Gaming platform used to compare memory impairments of rodents and humans with epilepsy

Date:
December 3, 2012
Source:
American Epilepsy Society (AES)
Summary:
A behavioral test widely used on rodents to study spatial learning and memory, the Morris water maze (MWM), was recreated using software developed to create custom video game environments. By creating a virtual reality analogue for humans, it was possible to obtain a direct comparison between the results of studies on a rodent model of temporal lobe epilepsy (TLE), whose spatial memory performance was found to be severely impaired, and patients with TLE.

A behavioral test widely used on rodents to study spatial learning and memory, the Morris water maze (MWM), was recreated using software developed to create custom video game environments. By creating a virtual reality analogue for humans, it was possible to obtain a direct comparison between the results of studies on a rodent model of temporal lobe epilepsy (TLE), whose spatial memory performance was found to be severely impaired, and patients with TLE.

The simulation program developed using the "Source Engine" (ValveTM) software was used to create an environment comparable to the submerged water platform of the Morris water maze. The novel research tool and the striking results it produced were presented today at the American Epilepsy Society's 66th annual meeting here at the San Diego Convention Center.

In this study by researchers from the Neurology department at the Geisel School of Medicine at Dartmouth and the Department of Neurosciences and Mental Health, UCL Institute of Child Health in London, UK, eleven healthy volunteers and six patients with epilepsy were presented with laptop computers and a gamepad controller. After a habituation period, the subjects were "dropped" in the water-filled arena and asked to find a submerged platform as quickly as possible. Electrophysiological recordings were made in the patients with epilepsy to assess oscillatory and single-unit activity during the task and their results showed striking parallels between the patients with epilepsy and the previous rodent data.

"The water-maze is a familiar research tool and the virtual reality version holds great promise for translational research" says Ali S. Titiz, a PhD candidate at the Geisel School of Medicine, and the first author of the study.


Story Source:

The above story is based on materials provided by American Epilepsy Society (AES). Note: Materials may be edited for content and length.


Cite This Page:

American Epilepsy Society (AES). "From rats to people: Gaming platform used to compare memory impairments of rodents and humans with epilepsy." ScienceDaily. ScienceDaily, 3 December 2012. <www.sciencedaily.com/releases/2012/12/121203081615.htm>.
American Epilepsy Society (AES). (2012, December 3). From rats to people: Gaming platform used to compare memory impairments of rodents and humans with epilepsy. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2012/12/121203081615.htm
American Epilepsy Society (AES). "From rats to people: Gaming platform used to compare memory impairments of rodents and humans with epilepsy." ScienceDaily. www.sciencedaily.com/releases/2012/12/121203081615.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins