Featured Research

from universities, journals, and other organizations

Biopolymer: Designer interfaces between biological and artificial systems

Date:
December 13, 2012
Source:
National Institute for Materials Science
Summary:
New developments in synthesis techniques have liberated the polymer MPC’s potential for a huge range of medical and biological applications.

Microsphere columns after passage of whole blood for 15 min (left) and scanning electron microscopy images of polymer-coated beads packed in the columns (right).
Credit: Copyright : Sci. Technol. Adv. Mater. Vol 13 (2012) p. 064101

In their recently published review article in the Science and Technology of Advanced Materials, Yasuhiko Iwasaki at Kansai University and Kazuhiko Ishihara at the University of Tokyo describe how developments in synthesis techniques have liberated the polymer MPC's potential for a huge range of medical and biological applications.

Related Articles


A polymer inspired by the lipids in cell membranes is proving an invaluable biomaterial. Like the cell membrane, the polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) can provide a surface for biological reactions to take place, but it can also suppress unfavourable processes.

In their recently published review article, Yasuhiko Iwasaki at Kansai University and Kazuhiko Ishihara at the University of Tokyo in Japan describe how developments in synthesis techniques by showing that the 2-methacryloyloxyethyl phosphorylcholine (MPC) have liberated the polymer's potential for a huge range of medical and biological applications.

In fact the polymers were already attracting interest in the early 1970s. However until more facile synthesis techniques were developed investigations were limited and the polymer was little understood. By 1999 MPC polymers were being produced on an industrial scale, allowing more substantial studies. MPC is easily polymerized in a range of architectures. The chemical can suppress reactions such as protein adsorption and cell adhesion and has a high and readily adjustable solubility in water. These versatile properties lend MPC polymers to a range of applications.

The authors also describe methods for generating the polymer for effective use in non-fouling coatings. Formed into poly(MPC) brush structures with specified chain architectures, they can also be used as surfaces for controlling cell functions. In addition, the researchers explain how surface modifications with MPC polymers are effective in improving blood compatibility. The polymers can suppress protein adsorption, platelet adhesion, and platelet activation at blood-contacting surfaces and they can also be solute permeable. As such they are well suited for coating cardiovascular applications such as stents, cardiopulmonary bypasses, and ventricular assist devices.

Based on the fact that "MPC and various kinds of MPC polymers are now available commercially worldwide, and many medical devices treated with MPC polymers are used in clinics," they underline how far research into applications of MPC has advanced, and indicate how many possibilities remain for exploiting the chemical further.


Story Source:

The above story is based on materials provided by National Institute for Materials Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yasuhiko Iwasaki, Kazuhiko Ishihara. Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces. Science and Technology of Advanced Materials, 2012; 13 (6): 064101 DOI: 10.1088/1468-6996/13/6/064101

Cite This Page:

National Institute for Materials Science. "Biopolymer: Designer interfaces between biological and artificial systems." ScienceDaily. ScienceDaily, 13 December 2012. <www.sciencedaily.com/releases/2012/12/121213103252.htm>.
National Institute for Materials Science. (2012, December 13). Biopolymer: Designer interfaces between biological and artificial systems. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2012/12/121213103252.htm
National Institute for Materials Science. "Biopolymer: Designer interfaces between biological and artificial systems." ScienceDaily. www.sciencedaily.com/releases/2012/12/121213103252.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microsoft Adds Robot Guards, Ushers In Sci-Fi Apocalypse

Microsoft Adds Robot Guards, Ushers In Sci-Fi Apocalypse

Newsy (Nov. 23, 2014) Microsoft has robotic security guards working at its Silicon Valley Campus. Video provided by Newsy
Powered by NewsLook.com
Toyota's Hydrogen Fuel-Cell Green Car Soon Available in the US

Toyota's Hydrogen Fuel-Cell Green Car Soon Available in the US

AFP (Nov. 21, 2014) Toyota presented its hydrogen fuel-cell compact car called "Mirai" to US consumers at the Los Angeles auto show. The car should go on sale in 2015 for around $60.000. It combines stored hydrogen with oxygen to generate its own power. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Google Announces Improvements To Balloon-Borne Wi-Fi Project

Google Announces Improvements To Balloon-Borne Wi-Fi Project

Newsy (Nov. 21, 2014) In a blog post, Google said its balloons have traveled 3 million kilometers since the start of Project Loon. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins