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Induction of adult cortical neurogenesis by an antidepressant

Date:
January 4, 2013
Source:
National Institute for Physiological Sciences
Summary:
The production of new neurons in the adult normal cortex in response to the antidepressant, fluoxetine, is reported in a new study.

The production of new neurons in the adult normal cortex in response to the antidepressant, fluoxetine, is reported in a study published online this week in Neuropsychopharmacology.

The research team, which is based at the Institute for Comprehensive Medical Science, Fujita Health University, Aichi, has previously demonstrated that neural progenitor cells exist at the surface of the adult cortex, and, moreover, that ischemia enhances the generation of new inhibitory neurons from these neural progenitor cells. These cells were accordingly named "Layer 1 Inhibitory Neuron Progenitor cells" (L1-INP). However, until now it was not known whether L1-INP-related neurogenesis could be induced in the normal adult cortex.

Tsuyoshi Miyakawa, Koji Ohira, and their colleagues employed fluoxetine, a selective serotonin reuptake inhibitor, and one of the most widely used antidepressants, to stimulate the production of new neurons from L1-INP cells. A large percentage of these newly generated neurons were inhibitory GABAergic interneurons, and their generation coincided with a reduction in apoptotic cell death following ischemia. This finding highlights the potential neuroprotective response induced by this antidepressant drug. It also lends further support to the postulation that induction of adult neurogenesis in cortex is a relevant prevention/treatment option for neurodegenerative diseases and psychiatric disorders.


Story Source:

The above story is based on materials provided by National Institute for Physiological Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Koji Ohira, Rika Takeuchi, Hirotaka Shoji and Tsuyoshi Miyakawa. Fluoxetine-Induced Cortical Adult Neurogenesis Open. Neuropsychopharmacology, 2013 DOI: 10.1038/npp.2013.2

Cite This Page:

National Institute for Physiological Sciences. "Induction of adult cortical neurogenesis by an antidepressant." ScienceDaily. ScienceDaily, 4 January 2013. <www.sciencedaily.com/releases/2013/01/130104101423.htm>.
National Institute for Physiological Sciences. (2013, January 4). Induction of adult cortical neurogenesis by an antidepressant. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2013/01/130104101423.htm
National Institute for Physiological Sciences. "Induction of adult cortical neurogenesis by an antidepressant." ScienceDaily. www.sciencedaily.com/releases/2013/01/130104101423.htm (accessed September 20, 2014).

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