Featured Research

from universities, journals, and other organizations

Heat Shock Proteins May Shed New Light on a Variety of Debilitating Diseases

Date:
January 28, 2013
Source:
University of California, Los Angeles (UCLA), Health Sciences
Summary:
Researchers, in a finding that runs counter to conventional wisdom, have discovered for the first time that a gene thought to express a protein in all cells that come under stress is instead expressed only in specific cell types.

UCLA researchers, in a finding that runs counter to conventional wisdom, have discovered for the first time that a gene thought to express a protein in all cells that come under stress is instead expressed only in specific cell types.

The group, from the Jules Stein Eye Institute and UCLA Pulmonary and Critical Care Medicine, focused on αB-Crystallin, a small heat shock protein. Heat shock proteins are a class of functionally-related proteins involved in the folding and unfolding of other proteins. Their expression is increased when cells are exposed to taxing environmental conditions, such as infection, inflammation, exercise, exposure to toxins and other stressors.

αB-Crystallin may be associated with certain cancers and could be developed into a biomarker to monitor for diseases such as multiple sclerosis, age-related macular degeneration, heart muscle degeneration and clouding of the eye lens. Any discoveries about how this protein is regulated and its molecular biology may reveal potential targets for novel therapies, said study first author Zhe Jing, a research associate in UCLA Pulmonary and Critical Care Medicine.

"If you use a certain cell type, this protein can be induced when the cells are stressed, but that doesn't happen in a different cell type," said Jing. "This novel finding does conflict with what has been thought, that this protein could be induced in any cell type."

The findings of this two-year study are published in the most recent issue of the journal Cell Stress and Chaperones, a peer-reviewed journal in the fields of cell stress response.

The UCLA team did the study using four cell lines -- two epithelial cells lines and two fibroblast cells lines. They found that the protein cannot be induced by stress in epithelial cells, in which 80 percent of cancers arise. It can, however, be induced in the fibroblasts that make up muscle tissue.

The significant finding in this investigation is that, in certain cell types, only one specific heat shock factor controls the expression of αB-Crystallin. For example, in the epithelial cell lines, it is heat shock factor 4 (HSF4), while a different heat shock factor, (HSF1), plays this role in the fibroblast cells lines.

In the past, the data has indicated that a heat shock factor could control the expression of αB-Crystallin randomly and equally. However, Jing's discovery overrides this rule. His findings strongly suggest the "preference" of the αB-Crystallin to heat shock factors in certain cells may be correlated with its versatility to various diseases.

"Considering the multiple roles of αB-Crystallin in so many diseases, the access of the HSF1 and HSF4 to the αB-Crystallin gene dictated by the certain cell type may be what is helping to cause certain diseases," Jing said. "If we can uncover the cascade of events that result in disease, we may be able to come up with strategies to block or interrupt that cascade."

Going forward, Jing and the research team will validate what they found in this study by examining single cells, which provides a greater challenge but may lead to further discoveries.

The study was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of California, Los Angeles (UCLA), Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zhe Jing, Rajendra K. Gangalum, Josh Z. Lee, Dennis Mock, Suraj P. Bhat. Cell-type-dependent access of HSF1 and HSF4 to αB-crystallin promoter during heat shock. Cell Stress and Chaperones, 2012; DOI: 10.1007/s12192-012-0386-7

Cite This Page:

University of California, Los Angeles (UCLA), Health Sciences. "Heat Shock Proteins May Shed New Light on a Variety of Debilitating Diseases." ScienceDaily. ScienceDaily, 28 January 2013. <www.sciencedaily.com/releases/2013/01/130128163338.htm>.
University of California, Los Angeles (UCLA), Health Sciences. (2013, January 28). Heat Shock Proteins May Shed New Light on a Variety of Debilitating Diseases. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2013/01/130128163338.htm
University of California, Los Angeles (UCLA), Health Sciences. "Heat Shock Proteins May Shed New Light on a Variety of Debilitating Diseases." ScienceDaily. www.sciencedaily.com/releases/2013/01/130128163338.htm (accessed April 24, 2014).

Share This



More Plants & Animals News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
Raw: Kangaroo Rescued from Swimming Pool

Raw: Kangaroo Rescued from Swimming Pool

AP (Apr. 24, 2014) A kangaroo was saved from drowning in a backyard suburban swimming pool in Australia's Victoria state on Thursday. Australian broadcaster Channel 7 showed footage of the kangaroo struggling to get out of the pool. (April 24) Video provided by AP
Powered by NewsLook.com
Could Marijuana Use Lead To Serious Heart Problems?

Could Marijuana Use Lead To Serious Heart Problems?

Newsy (Apr. 24, 2014) A new study says marijuana use could lead to serious heart-related complications. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins