Featured Research

from universities, journals, and other organizations

New study of the molecular roots of recurrent bladder infections could lead to a vaccine

Date:
February 14, 2013
Source:
Cell Press
Summary:
Urinary tract infections are the second most common bacterial infection in humans, and many of them are recurrent. A new study reveals the cellular and molecular basis of recurrent bladder infections and suggests possible treatment strategies, such as vaccines, to prevent this common problem.

This is an array of mast cells in a whole mount image of the mouse bladder.
Credit: Immunity, Chan et al.

Urinary-tract infections are the second most common bacterial infection in humans, and many of them are recurrent. A study published Feb. 14 by Cell Press in the journal Immunity reveals the cellular and molecular basis of recurrent bladder infections and suggests possible treatment strategies, such as vaccines, to prevent this common problem.

"Our study shows for the first time that the bladder is unable to mount an effective immune response to bacteria, which could explain the high frequency of recurrent infections," says senior study author Soman Abraham of Duke University Medical Center. "These observations give us a new understanding of how immune responses are regulated in the bladder and may have implications for the treatment of recurrent infections."

Urinary-tract infections are caused by Escherichia coli (E. coli), and the bladder in particular is prone to recurrent infections, but it is not known why. Some organs, such as the gut, that store waste products are considered "immune-privileged sites," which need to tolerate the presence of microbes. As a result, the immune system does not activate as readily. Similarly, the bladder might require subdued immune responses to tolerate its contents (e.g., proteins in urine), prevent autoimmunity, and minimize tissue damage. If the bladder were an immune-privileged site, it might explain why it is prone to recurrent infections. But until now, the bladder has not been considered an immune-privileged site, so it has not been clear how this organ balances host defense with microbe tolerance.

In the new study, Abraham and his team found that E. coli persists in the bladders of mice for weeks after initial infection. These mice failed to produce antibodies against E. coli in response to initial infection or recurrent infection, suggesting that immune memory was impaired. The persistence of bacteria and suppressed immune responses in the bladder were mediated by the production of the molecule interleukin-10 by mast cells, which previously were known for their role in mounting immune responses against bacteria during the early stages of bladder infection. The results reveal that mast cells play a complex and key role in balancing host defense and tolerance in the bladder and in maintaining this organ as an immune-privileged site.

"The study suggests that provoking a strong immune response in the bladder through vaccination may be a possible strategy to prevent recurrent infections," Abraham says. "Moreover, the findings could influence our understanding of additional conditions involving the bladder, such as bladder cancers."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. CherylY. Chan, AshleyL. St.John, SomanN. Abraham. Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection. Immunity, 2013; DOI: 10.1016/j.immuni.2012.10.019

Cite This Page:

Cell Press. "New study of the molecular roots of recurrent bladder infections could lead to a vaccine." ScienceDaily. ScienceDaily, 14 February 2013. <www.sciencedaily.com/releases/2013/02/130214133919.htm>.
Cell Press. (2013, February 14). New study of the molecular roots of recurrent bladder infections could lead to a vaccine. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2013/02/130214133919.htm
Cell Press. "New study of the molecular roots of recurrent bladder infections could lead to a vaccine." ScienceDaily. www.sciencedaily.com/releases/2013/02/130214133919.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

More Coverage


Defect in Immune Memory May Cause Repeat Bladder Infections

Feb. 14, 2013 Recurrent bladder infections, which are especially common among women, may result from a defect among the bladder's immune fighters that keeps them from remembering previous bacterial ... read more
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins