Featured Research

from universities, journals, and other organizations

Natural probiotic for osteoporosis? Building healthy bones takes guts

Date:
February 14, 2013
Source:
Michigan State University
Summary:
In what could be an early step toward new treatments for people with osteoporosis, scientists report that a natural probiotic supplement can help male mice produce healthier bones.

MSU researchers scan mouse femurs to see how a probiotic supplement affects bone density.
Credit: Matt Hallowell

In what could be an early step toward new treatments for people with osteoporosis, scientists at Michigan State University report that a natural probiotic supplement can help male mice produce healthier bones.

Interestingly, the same can't be said for female mice, the researchers report in the Journal of Cellular Physiology.

"We know that inflammation in the gut can cause bone loss, though it's unclear exactly why," said lead author Laura McCabe, a professor in MSU's departments of Physiology and Radiology. "The neat thing we found is that a probiotic can enhance bone density."

Probiotics are microorganisms that can help balance the immune system. For the study, the researchers fed the mice Lactobacillus reuteri, a probiotic known to reduce inflammation, a sometimes harmful effect of the body's immune response to infection.

"Through food fermentation, we've been eating bacteria that we classify as probiotics for thousands of years," said co-author Robert Britton, associate professor in the Department of Microbiology and Molecular Genetics. "There's evidence that this bacterium as a species has co-evolved with humans. It's indigenous to our intestinal tracts and is something that, if missing, might cause problems."

In the study, the male mice showed a significant increase in bone density after four weeks of treatment. There was no such effect when the researchers repeated the experiment with female mice, an anomaly they're now investigating.

By 2020, half of all Americans over 50 are expected to have low bone density or osteoporosis, according to the National Osteoporosis Foundation. About one in two women and one in four men over 50 will break a bone due to osteoporosis.

Drugs to prevent bone loss in osteoporosis patients are already in wide use, but over the long term they can disrupt the natural remodeling of bone tissue and could potentially have negative side effects that include unusual bone fractures and joint and muscle pain.

McCabe and Britton are quick to point out that this line of research is in its early stages and that results in mice don't always translate to humans. But they're hopeful the new study could point the way toward osteoporosis drugs that aren't saddled with such side effects, especially for people who lose bone density from an early age because of another chronic condition.

"People tend to think of osteoporosis as just affecting postmenopausal women, but what they don't realize is that it can occur with other conditions such as inflammatory bowel disease and Type 1 diabetes," she said. "You don't want to put your child on medications that reduce bone remodeling for the rest of their life, so something natural could be useful for long-term treatment of bone loss that begins at childhood."

The research was supported by grants from the National Institutes of Health and MSU. Research assistants Regina Irwin and Laura Schaefer co-authored the paper.


Story Source:

The above story is based on materials provided by Michigan State University. Note: Materials may be edited for content and length.


Cite This Page:

Michigan State University. "Natural probiotic for osteoporosis? Building healthy bones takes guts." ScienceDaily. ScienceDaily, 14 February 2013. <www.sciencedaily.com/releases/2013/02/130214194138.htm>.
Michigan State University. (2013, February 14). Natural probiotic for osteoporosis? Building healthy bones takes guts. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2013/02/130214194138.htm
Michigan State University. "Natural probiotic for osteoporosis? Building healthy bones takes guts." ScienceDaily. www.sciencedaily.com/releases/2013/02/130214194138.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins