Featured Research

from universities, journals, and other organizations

'Gateway' in nucleus has second important job no one noticed before

Date:
March 7, 2013
Source:
University of Alberta Faculty of Medicine & Dentistry
Summary:
Medical researchers have discovered that the "gateway" known to control the movement of molecules in and out of a cell's nucleus appears to play another critically important role -- one no one had noticed until now.

UAlberta medical researchers and their American colleagues have discovered that the "gateway" known to control the movement of molecules in and out of a cell's nucleus appears to play another critically important role -- one no one had noticed until now.

Related Articles


These "gateways" have a second key job in a cell -- the ability to control the structure of chromosomes and the DNA linked to those chromosomes. This impacts what genes produce or express. The discovery gives scientists a new way to investigate the triggers for various kinds of disease, says Richard Wozniak, the principal investigator with the Faculty of Medicine & Dentistry, who worked on the discovery with collaborators from the Institute for Systems Biology (Seattle).

"This discovery may explain links between disease and defects in these gateways," he says.

"Our studies provide new insights into how the nucleus is organized and how the genetic material it houses is used, including important information about the jobs genes do. When cells have to adapt to their environment, they need to change their gene expressions pattern. If this isn't done right, diseases such as cancer or heart disease occur. Our work also provides insight into why many viral infections target this gateway for their survival."

The research team's discovery was recently published in the peer-reviewed journal, Cell.

Wozniak and his team are continuing their research in this area. They want to learn more about this new mechanism when it functions properly, and what causes it to malfunction. Uncovering the key players in this new mechanism are also key, he says.

"We want to understand how these gateways are functioning at a molecular level -- what makes them capable of altering the structure of chromosomes and making other key changes? That is our next step," says Wozniak, who is a researcher with the Department of Cell Biology.

The Canadian Institutes of Health Research, the Howard Hughes Medical Institute, and Alberta Innovates -- Health Solutions provided funding for the team's work.


Story Source:

The above story is based on materials provided by University of Alberta Faculty of Medicine & Dentistry. The original article was written by Raquel Maurier. Note: Materials may be edited for content and length.


Journal Reference:

  1. DavidW. VandeVosse, Yakun Wan, DiegoL. Lapetina, Wei-Ming Chen, Jung-Hsien Chiang, JohnD. Aitchison, RichardW. Wozniak. A Role for the Nucleoporin Nup170p in Chromatin Structure and Gene Silencing. Cell, 2013; 152 (5): 969 DOI: 10.1016/j.cell.2013.01.049

Cite This Page:

University of Alberta Faculty of Medicine & Dentistry. "'Gateway' in nucleus has second important job no one noticed before." ScienceDaily. ScienceDaily, 7 March 2013. <www.sciencedaily.com/releases/2013/03/130307145436.htm>.
University of Alberta Faculty of Medicine & Dentistry. (2013, March 7). 'Gateway' in nucleus has second important job no one noticed before. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2013/03/130307145436.htm
University of Alberta Faculty of Medicine & Dentistry. "'Gateway' in nucleus has second important job no one noticed before." ScienceDaily. www.sciencedaily.com/releases/2013/03/130307145436.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dog Flu Spreading in Midwestern States

Dog Flu Spreading in Midwestern States

AP (Apr. 17, 2015) Dog flu is spreading in several Midwestern states. Dog daycare centers and veterinary offices are taking precautions. (April 17) Video provided by AP
Powered by NewsLook.com
Raw: Rare Whale Spotted in Gulf of Mexico

Raw: Rare Whale Spotted in Gulf of Mexico

AP (Apr. 17, 2015) Researchers from the E/V Nautilus had quite a surprise Tuesday, when a curious sperm whale swam around their remotely operated vehicle in the Gulf of Mexico. Cameras captured the encounter. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins