Featured Research

from universities, journals, and other organizations

Immune system can delay healing of bone fractures

Date:
March 21, 2013
Source:
Charité - Universitätsmedizin Berlin
Summary:
Medical researchers have succeeded in demonstrating an association between delayed bone fracture healing and increased concentration of specific immune cells in the blood of the patient. Results of the study show that the adaptive immune system responds to the fracture in a similar way as to an infection and attempts to fight against it.

Researchers at Charité -- Universitätsmedizin Berlin have succeeded in demonstrating an association between delayed bone fracture healing and increased concentration of specific immune cells in the blood of the patient. Results of the study show that the adaptive immune system responds to the fracture in a similar way as to an infection and attempts to fight against it.

Related Articles


The study appears in the current issue of the journal Science Translational Medicine.

In their study, the team of researchers led by Prof. Georg Duda and Prof. Hans-Dieter Volk, directors of the Berlin-Brandenburg Center for Regenerative Therapies (BCRT) at Charité, examined the role of the acquired immune system in the process of fracture healing. Their study focused on so called CD8+ T-cells, which recognize pathogens (e.g. a bacteria or viruses) through specific receptors and eliminate them by releasing certain proteins (cytokines). The researchers found an association between delayed bone healing and elevated concentrations of a sub-group of CD8+ T-cells -- known as TEMRA cells -- in the patient's blood. These cells indicate an aged immune system.

They do not require a direct pathogen contact to become activated, but instead, respond directly to inflammatory signals. "Our study suggests that TEMRA cells misinterpret the fracture as a pathogen infection. In case of a fracture, they migrate to the side of injury and locally release specific cytokines, which compromises the function of pro-regenerative cells, resulting in a delayed healing," says Dr. Simon Reinke, one of the two lead authors of the study. The researcher then took these studies into mice and found that depletion of CD8+ T cells by a specific antibody therapy significantly improved the healing, whereas adding CD8+ T cells impaired fracture regeneration.

"Our study establishes a mechanistic link between the individual immune profile and the fracture healing outcome," states the other lead author of the study, Dr. Sven Geißler. In the future, this knowledge could be used for the early prediction of the healing outcome and for the targeted intervention. Thus, it opens the opportunity for the development of new therapies to improve and accelerate the healing of bone fractures or potentially other tissue injuries.


Story Source:

The above story is based on materials provided by Charité - Universitätsmedizin Berlin. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Reinke, S. Geissler, W. R. Taylor, K. Schmidt-Bleek, K. Juelke, V. Schwachmeyer, M. Dahne, T. Hartwig, L. Akyuz, C. Meisel, N. Unterwalder, N. B. Singh, P. Reinke, N. P. Haas, H.-D. Volk, G. N. Duda. Terminally Differentiated CD8 T Cells Negatively Affect Bone Regeneration in Humans. Science Translational Medicine, 2013; 5 (177): 177ra36 DOI: 10.1126/scitranslmed.3004754

Cite This Page:

Charité - Universitätsmedizin Berlin. "Immune system can delay healing of bone fractures." ScienceDaily. ScienceDaily, 21 March 2013. <www.sciencedaily.com/releases/2013/03/130321092945.htm>.
Charité - Universitätsmedizin Berlin. (2013, March 21). Immune system can delay healing of bone fractures. ScienceDaily. Retrieved April 2, 2015 from www.sciencedaily.com/releases/2013/03/130321092945.htm
Charité - Universitätsmedizin Berlin. "Immune system can delay healing of bone fractures." ScienceDaily. www.sciencedaily.com/releases/2013/03/130321092945.htm (accessed April 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, April 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) — Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) — The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) — The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins